Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Platt, Kenneth B. ; Tucker, Bradley J. ; Halbur, Patrick G. ; Tiawsirisup, Sonthaya ; Blitvich, Bradley J. ; ... More +
Platt, Kenneth B. ; Tucker, Bradley J. ; Halbur, Patrick G. ; Tiawsirisup, Sonthaya ; Blitvich, Bradley J. ; Fabiosa, Flor G. ; Bartholomay, Lyric C. ; Rowley, Wayne A. Less -
Description:
In eastern chipmunks (Tamias striatus) inoculated intramuscularly with 101.5 to 105.7 PFU of West Nile virus (WNV), serum titers developed sufficient to infect Aedes triseriatus (Say), Ae. vexans (Meigen), and Culex pipiens (L.). Mean titers (95% confidence interval) of 8 chipmunks were 103.9(3.3-4.5), 106.7(6.4-7.0), and 105.8(4.1-7.5) PFU/mL on days 1-3 postinoculation (p.i.) and 105.8 PFU/mL in 1 chipmunk on day 4 p.i. Mean estimated days that WNV titers were >104.8 and >105.6 were 1.7 (1.1-2.3) and 1.4 (1.0-1.6). The longest period of viremia >104.8 PFU/mL was 3-4 days. WNV antigen was detected in the small intestine of 2 chipmunks and the kidneys of 4 chipmunks by immunohistochemistry. WNV also was detected in urine, saliva, and feces of some chipmunks. These data suggest chipmunks might play a role in enzootic WNV cycles and be an amplifying host for mosquitoes that could infect humans.
Subjects:
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Aedes Aedes Triseriatus Aedes Vexans Animals Chipmunks Culex Culex Pipiens Disease Models, Animal Disease Reservoirs Research Sciuridae Viremia West Nile Fever West Nile Virus
Source:
Emerg Infect Dis. 13(6):831-837.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:38d6a0a70bcd333ea34aba53ba16cbf5d5dd1e83956591b219e9b87cad0405fc
Download URL:
https://stacks.cdc.gov/view/cdc/16499/cdc_16499_DS1.pdf
File Type:

Supporting Files

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