Maternal Exposure to Tap Water Disinfection By-Products and Risk of Selected Congenital Heart Defects

Details

• Alternative Title:
  Birth Defects Res
• Personal Author:
  Michalski, Adrian M. ; Luben, Thomas J. ; Zaganjor, Ibrahim ; Rhoads, Anthony ; Romitti, Paul A. ; Conway, Kristin M. ; Langlois, Peter H. ; Feldkamp, Marcia L. ; Nembhard, Wendy N. ; Reefhuis, Jennita ; Yazdy, Mahsa M. ; Lin, Angela E. ; Desrosiers, Tania A. ; Hoyt, Adrienne T. ; Browne, Marilyn L.
• Corporate Authors:
  The National Birth Defects Prevention Study
• Description:
  Background:
  
  The use of chlorine to treat drinking water produces disinfection by-products (DBPs), which have been associated with congenital heart defects (CHDs) in some studies.
  
  Methods:
  
  Using National Birth Defects Prevention Study data, we linked geocoded residential addresses to public water supply measurement data for DBPs. Self-reported water consumption and filtration methods were used to estimate maternal ingestion of DBPs. We estimated adjusted odds ratios and 95% confidence intervals using logistic regression controlling for maternal age, education, body mass index (BMI), race/ethnicity, and study site to examine associations between CHDs and both household DBP level and estimated ingestion of DBPs.
  
  Results:
  
  Household DBP exposure was assessed for 2717 participants (1495 cases and 1222 controls). We observed a broad range of positive, null, and negative estimates across eight specific CHDs and two summary exposures (trihalomethanes and haloacetic acids) plus nine individual DBP species. Examining ingestion exposure among 2488 participants (1347 cases, 1141 controls) produced similarly inconsistent results.
  
  Conclusions:
  
  Assessing both household DBP level and estimated ingestion of DBPs, we did not find strong evidence of an association between CHDs and DBPs. Despite a large study population, DBP measurements were available for less than half of participant addresses, limiting study power.
  
  
• Subjects:
  Adult Case-Control Studies Disinfectants Disinfection Drinking Water Female Heart Defects, Congenital Humans Male Maternal Exposure Odds Ratio Pregnancy Risk Factors Trihalomethanes Water Pollutants, Chemical Water Purification Water Supply

  More +
• Keywords:
  Congenital Heart Defects Disinfection By-products Ingestion Public Water Supply
• Source:
  Birth Defects Res. 116(9):e2391
• Pubmed ID:
  39212068
• Pubmed Central ID:
  PMC11440226
• Document Type:
  Journal Article
• Funding:
  CDP 13-003/HX/HSRD VAUnited States/ ; FOA #DD09-001/CC/CDC HHSUnited States/ ; FOA #DD13-003/CC/CDC HHSUnited States/ ; PA #96043/CC/CDC HHSUnited States/ ; CC999999/ImCDC/Intramural CDC HHSUnited States/ ; EP-D-18-001/EPA/EPAUnited States/ ; PA #02081/CC/CDC HHSUnited States/ ; NOFO #DD18-001/CC/CDC HHSUnited States/
• Volume:
  116
• Issue:
  9
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:61b5c170451d862e34a0192cd51b34f0c81befb2f377515959fbd37a06cbb907eb98a46dc740993af5a863880d856d310c685b2245cb4f35f89a753db96511bc
• Download URL:
  https://stacks.cdc.gov/view/cdc/164629/cdc_164629_DS1.pdf
• File Type:
  [PDF - 667.55 KB ]