Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid1305.060572
Personal Author:
Uiprasertkul, Mongkol ; Kitphati, Rungrueng ; Puthavathana, Pilaipan ; Kriwong, Romchat ; Kongchanagul, Alita ; ... More +
Uiprasertkul, Mongkol ; Kitphati, Rungrueng ; Puthavathana, Pilaipan ; Kriwong, Romchat ; Kongchanagul, Alita ; Ungchusak, Kumnuan ; Angkasekwinai, Suwimon ; Chokephaibulkit, Kulkanya ; Srisook, Kanittar ; Vanprapar, Nirun ; Auewarakul, Prasert Less -
Description:
The pathogenesis of avian influenza A (H5N1) virus in humans has not been clearly elucidated. Apoptosis may also play an important role. We studied autopsy specimens from 2 patients who died of infection with this virus. Apoptosis was observed in alveolar epithelial cells, which is the major target cell type for the viral replication. Numerous apoptotic leukocytes were observed in the lung of a patient who died on day 6 of illness. Our data suggest that apoptosis may play a major role in the pathogenesis of influenza (H5N1) virus in humans by destroying alveolar epithelial cells. This pathogenesis causes pneumonia and destroys leukocytes, leading to leukopenia, which is a prominent clinical feature of influenza (H5N1) virus in humans. Whether observed apoptotic cells were a direct result of the viral replication or a consequence of an overactivation of the immune system requires further studies.
Subject:
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Apoptosis
Autopsy
Humans
Influenza, Human
Influenza A Virus, H5N1 Subtype
Male
Middle Aged
Pulmonary Alveoli
Respiratory Mucosa
RNA, Viral

Source:
Emerg Infect Dis. 13(5):708-712.
Document Type:
Journal Article
Place as Subject:
Thailand
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:ce2c0ea74351db9cbeaf16966061a65a4ac563ccf8730da4c87e54114ed8e00c
File Type:

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