Content
and Copyright
i
Apoptosis and Pathogenesis of Avian Influenza A (H5N1) Virus in Humans
-
Published Date:
May 2007
Publisher's site:Source:Emerg Infect Dis. 13(5):708-712.
[PDF-299.21 KB]
Details:
-
Alternative Title:Emerg Infect Dis
-
Personal Author:
-
Description:The pathogenesis of avian influenza A (H5N1) virus in humans has not been clearly elucidated. Apoptosis may also play an important role. We studied autopsy specimens from 2 patients who died of infection with this virus. Apoptosis was observed in alveolar epithelial cells, which is the major target cell type for the viral replication. Numerous apoptotic leukocytes were observed in the lung of a patient who died on day 6 of illness. Our data suggest that apoptosis may play a major role in the pathogenesis of influenza (H5N1) virus in humans by destroying alveolar epithelial cells. This pathogenesis causes pneumonia and destroys leukocytes, leading to leukopenia, which is a prominent clinical feature of influenza (H5N1) virus in humans. Whether observed apoptotic cells were a direct result of the viral replication or a consequence of an overactivation of the immune system requires further studies.
-
Subject:
-
Document Type:
-
Collection(s):
-
Main Document Checksum:
- File Type:
-
Supporting Files:
text/plain 
image/gif 
image/jpeg 
image/gif 
image/jpeg 
image/gif 
image/jpeg
text/plain
No Related Documents.
You May Also Like:
-
Published Date:Source:Description:File Type:[PDF - 357.49 KB]
File Type:[PDF - 357.49 KB]
Published Date:Source:Description:File Type:[PDF - 2.02 MB]
File Type:[PDF - 2.02 MB]
Published Date:Source:Description:File Type:[PDF - 738.92 KB]
File Type:[PDF - 738.92 KB]
Published Date:Source:Description:File Type:[PDF - 1.49 MB]
File Type:[PDF - 1.49 MB]
Published Date:Source:Description:File Type:[PDF - 547.99 KB]
File Type:[PDF - 547.99 KB]
Have Questions?
Visit CDC Info
Email
CDC-INFO
Open 24/7
CDC INFORMATION
CONNECT WITH CDC
