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Apoptosis and Pathogenesis of Avian Influenza A (H5N1) Virus in Humans
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  1. H5N1 pathogenesis studies in mammalian models
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    Published Date:
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    Virus Res. 178(1):168-185.
    Description:
    H5N1 influenza viruses are capable of causing severe disease and death in humans, and represent a potential pandemic subtype should they acquire a transmissible phenotype. Due to the expanding host and geographic range of this virus subtype, there is...
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  2. Influenza A virus nucleoprotein induces apoptosis in human airway epithelial cells: implications of a novel interaction between nucleoprotein and host protein Clusterin
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    Tripathi, S; Batra, J; Cao, W; Sharma, K; Patel, J R; Ranjan, P; Kumar, A; Katz, J M; Cox, N J; Lal, R B; Sambhara, S; Lal, S K;
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    Cell Death Dis. 2013; 4(3):e562-.
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    Apoptosis induction is an antiviral host response, however, influenza A virus (IAV) infection promotes host cell death. The nucleoprotein (NP) of IAV is known to contribute to viral pathogenesis, but its role in virus-induced host cell death was hith...
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  3. Role of Position 627 of PB2 and the Multibasic Cleavage Site of the Hemagglutinin in the Virulence of H5N1 Avian Influenza Virus in Chickens and Ducks
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    Schat, Karel A.; Bingham, John; Butler, Jeff M.; Chen, Li-Mei; Lowther, Sue; Crowley, Tamsyn M.; Moore, Robert J.; Donis, Ruben O.; Lowenthal, John W.;
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    Feb 21 2012
    Source:
    PLoS One. 2012; 7(2).
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    Highly pathogenic H5N1 avian influenza viruses have caused major disease outbreaks in domestic and free-living birds with transmission to humans resulting in 59% mortality amongst 564 cases. The mutation of the amino acid at position 627 of the viral...
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  4. H5N1 and 1918 Pandemic Influenza Virus Infection Results in Early and Excessive Infiltration of Macrophages and Neutrophils in the Lungs of Mice
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    PLoS Pathog. 2008; 4(8).
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