Distinct Transmission Cycles of Leishmania tropica in 2 Adjacent Foci, Northern Israel

Svobodova, Milena; Votypka, Jan; Peckova, Jitka; Dvorak, Vít; Nasereddin, Abedelmajeed; Baneth, Gad; Sztern, Julia; Kravchenko, Vasiliy; Orr, Amnon; Meir, David; Schnur, Lionel F.; Volf, Petr; Warburg, Alon

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Distinct Transmission Cycles of Leishmania tropica in 2 Adjacent Foci, Northern Israel

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Dec 2006
By Svobodova, Milena ; Votypka, Jan ; Peckova, Jitka ; ...

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Alternative Title:

Emerg Infect Dis
Personal Author:

Svobodova, Milena ; Votypka, Jan ; Peckova, Jitka ; Dvorak, Vít ; Nasereddin, Abedelmajeed ; Baneth, Gad ; Sztern, Julia ; Kravchenko, Vasiliy ; Orr, Amnon ; Meir, David ; Schnur, Lionel F. ; Volf, Petr ; Warburg, Alon
Description:

Transmission of Leishmania tropica was studied in 2 adjacent foci in Israel where vector populations differ. Only Phlebotomus sergenti was found infected with L. tropica in the southern focus; P. arabicus was the main vector in the northern focus. Rock hyraxes (Procavia capensis) were incriminated as reservoir hosts in both foci. L. tropica strains from the northern focus isolated from sand flies, cutaneous leishmaniasis cases, and rock hyraxes were antigenically similar to L. major, and strains from the southern focus were typically L. tropica. Laboratory studies showed that P. arabicus is a competent vector of L. tropica, and P. sergenti is essentially refractory to L. tropica from the northern focus. Susceptibility of P. arabicus may be mediated by O glycoproteins on the luminal surface of its midgut. The 2 foci differ with respect to parasites and vectors, but increasing peridomestic rock hyrax populations are probably responsible for emergence of cutaneous leishmaniasis in both foci.
Subjects:

Animals Cutaneous Leishmaniasis Disease Reservoirs DNA, Protozoan DNA, Ribosomal Spacer Female Fluorescent Antibody Technique, Indirect Hyraxes Insect Vectors Israel Leishmaniasis, Cutaneous Leishmania Tropica Male Phlebotomus Arabicus Phlebotomus Sergenti Polymerase Chain Reaction Procavia Capensis Psychodidae Research Rock Hyrax Sand Flies Zoonosis
Source:

Emerg Infect Dis. 12(12):1860-1868.
Document Type:

Journal Article
Volume:

12
Issue:

12
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:d887cb24c2fdfb9f18995b8070dd61d764e7500ed46d9c262e992fa5c7dcee02
Download URL:

https://stacks.cdc.gov/view/cdc/16341/cdc_16341_DS1.pdf
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[PDF - 471.69 KB ]

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