Determinants of Cluster Size in Large, Population-Based Molecular Epidemiology Study of Tuberculosis, Northern Malawi

Glynn, Judith R.; Crampin, Amelia C.; Traore, Hamidou; Chaguluka, Steve; Mwafulirwa, Donex T.; Alghamdi, Saad; Ngwira, Bagrey M.M.; Yates, Malcolm D.; Drobniewski, Francis D.; Fine, Paul E.M.

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Determinants of Cluster Size in Large, Population-Based Molecular Epidemiology Study of Tuberculosis, Northern Malawi

Supporting Files Public Domain

Jul 2008
By Glynn, Judith R. ; Crampin, Amelia C. ; Traore, Hamidou ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Glynn, Judith R. ; Crampin, Amelia C. ; Traore, Hamidou ; Chaguluka, Steve ; Mwafulirwa, Donex T. ; Alghamdi, Saad ; Ngwira, Bagrey M.M. ; Yates, Malcolm D. ; Drobniewski, Francis D. ; Fine, Paul E.M.
Description:

Tuberculosis patients with identical strains of Mycobacterium tuberculosis are described as clustered. Cluster size may depend on patient or strain characteristics. In a 7-year population-based study of tuberculosis in Karonga District, Malawi, clusters were defined by using IS6110 restriction fragment length polymorphism, excluding patterns with <5 bands. Spoligotyping was used to compare strains with an international database. Among 682 clustered patients, cluster size ranged from 2 to 37. Male patients, young adults, and town residents were over-represented in large clusters. Cluster size was not associated with HIV status or death from tuberculosis. Spoligotypes from 9 (90%) of 10 large cluster strains were identical or very similar (1 spacer different) to common spoligotypes found elsewhere, compared with 37 (66%) of 56 of those from nonclustered patients (p = 0.3). Large clusters were associated with factors likely to be related to social mixing, but spoligotypes of common strains in this setting were also common types elsewhere, consistent with strain differences in transmissibility.
Subjects:

Adult Age Distribution Cluster Analysis DNA Fingerprinting Female Hiv Infections Humans Male Middle Aged Molecular Epidemiology Research Sex Distribution
Source:

Emerg Infect Dis. 14(7):1060-1066.
Document Type:

Journal Article
Place as Subject:

Malawi
Location:

Africa
Volume:

14
Issue:

7
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:1564bf01840c4bc55818e9b6a792a037151571cc8275f15f1bffbf380e69a971
Download URL:

https://stacks.cdc.gov/view/cdc/16332/cdc_16332_DS1.pdf
File Type:

[PDF - 300.69 KB ]

File Language:

English

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