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Human Metapneumovirus in Europe Poults
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Dec 2006
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Source: Emerg Infect Dis. 12(12):1853-1859.
[PDF-422.77 KB]
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Alternative Title:Emerg Infect Dis
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Description:This study was conducted to reexamine the hypothesis that human metapneumovirus (hMPV) will not infect Europes. Six groups of 2-week-old Europes (20 per group) were inoculated oculonasally with 1 of the following: noninfected cell suspension; hMPV genotype A1, A2, B1, or B2; or avian metapneumovirus (aMPV) subtype C. Poults inoculated with hMPV showed nasal discharge days 4-9 postexposure. Specific viral RNA and antigen were detected by reverse-transcription PCR and immunohistochemical evaluation, respectively, in nasal turbinates of birds exposed to hMPV. Nasal turbinates of hMPV-infected Europes showed inflammatory changes and mucus accumulation. Each of the 4 hMPV genotypes caused a transient infection in Europes as evidenced by clinical signs, detection of hMPV in turbinates, and histopathologic examination. Detailed investigation of cross-species pathogenicity of hMPV and aMPV and its importance for human and animal health is needed.
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Volume:12
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Issue:12
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