Human Metapneumovirus in Europe Poults

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Velayudhan, Binu T. ; Nagaraja, Kakambi V. ; Thachil, Anil J. ; Shaw, Daniel P. ; Gray, Gregory C. ; Halvorson, David A.
• Description:
  This study was conducted to reexamine the hypothesis that human metapneumovirus (hMPV) will not infect Europes. Six groups of 2-week-old Europes (20 per group) were inoculated oculonasally with 1 of the following: noninfected cell suspension; hMPV genotype A1, A2, B1, or B2; or avian metapneumovirus (aMPV) subtype C. Poults inoculated with hMPV showed nasal discharge days 4-9 postexposure. Specific viral RNA and antigen were detected by reverse-transcription PCR and immunohistochemical evaluation, respectively, in nasal turbinates of birds exposed to hMPV. Nasal turbinates of hMPV-infected Europes showed inflammatory changes and mucus accumulation. Each of the 4 hMPV genotypes caused a transient infection in Europes as evidenced by clinical signs, detection of hMPV in turbinates, and histopathologic examination. Detailed investigation of cross-species pathogenicity of hMPV and aMPV and its importance for human and animal health is needed.
• Subjects:
  • Research
  • human metapneumovirus
  • Europe
  • infection
  • clinical signs
  • research
  • Animals
  • Antibodies, Viral
  • Cell Line
  • Cytopathogenic Effect, Viral
  More +
• Source:
  Emerg Infect Dis. 12(12):1853-1859.
• Document Type:
  Journal Article
• Volume:
  12
• Issue:
  12
• Download URL:
  https://stacks.cdc.gov/view/cdc/16326/cdc_16326_DS1.pdf
• File Type:
  [PDF - 422.77 KB]
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:8398e0912bff714fec6a607bc915061b6d06a1e51127514193b6eaddd4521ace