Active Cytomegalovirus Infection in Patients with Septic Shock

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  von Müller, Lutz ; Klemm, Anke ; Weiss, Manfred ; Schneider, Marion ; Suger-Wiedeck, Heide ; Durmus, Nilgün ; Hampl, Walter ; Mertens, Thomas
• Description:
  Cytomegalovirus (CMV) is a pathogen of emerging importance for patients with septic shock. In this prospective study, 25 immunocompetent CMV-seropositive patients with septic shock and an intensive care unit stay of > or =7 days were monitored by using quantitative pp65-antigenemia assay, shell vial culture, and virus isolation. Within 2 weeks, active CMV infection with low-level pp65-antigenemia (median 3 positive/5x10(5) leukocytes) developed in 8 (32%) patients. Infection was controlled within a few weeks (median 26 days) without use of antiviral therapy. Duration of intensive care and mechanical ventilation were significantly prolonged in patients with active CMV infection. CMV reactivation was associated with concomitant herpes simplex virus reactivation (p = 0.004). The association between active CMV infection and increased illness could open new therapeutic options for patients with septic shock. Future interventional studies are required.
• Subjects:
  Adult Aged Cytomegalovirus Cytomegalovirus Infections Diagnostic Assays Female Herpes Simplex Herpes Simplex Virus Humans Male Middle Aged Phosphoproteins Pilot Projects Prospective Studies Reactivation Research Sepsis Shock, Septic Simplexvirus Viral Matrix Proteins

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• Source:
  Emerg Infect Dis. 12(10):1517-1522.
• Document Type:
  Journal Article
• Volume:
  12
• Issue:
  10
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:dc0a89f0acc1ddb53b74965a8882629a2d51d653afbe3077a6fdaa33ca63f970
• Download URL:
  https://stacks.cdc.gov/view/cdc/16313/cdc_16313_DS1.pdf
• File Type:
  [PDF - 231.46 KB ]