Fluoroquinolones and Risk for Methicillin-Resistant Staphylococcus aureus, Canada

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  LeBlanc, Louiselle ; Pépin, Jacques ; Toulouse, Krystel ; Ouellette, Marie-France ; Coulombe, Marie-Andrée ; Corriveau, Marie-Pier ; Alary, Marie-Eve
• Description:
  Receipt of fluoroquinolones was the predominant risk factor for Clostridium difficile-associated disease (CDAD) during an epidemic in Quebec, Canada. To determine the role of antimicrobial drugs in facilitating healthcare-associated methicillin-resistant Staphylococcus aureus (MRSA) colonization and infection and to compare this role with their effects on methicillin-susceptible S. aureus infection and CDAD, we conducted a retrospective cohort study of patients in a Quebec hospital. For 7371 episodes of care, data were collected on risk factors, including receipt of antimicrobial drugs. Crude and adjusted hazard ratios (AHR) were calculated by Cox regression. Of 150 episodes of MRSA colonization and 23 of MRSA infection, fluoroquinolones were the only antimicrobials that increased risk for colonization (AHR 2.57, 95% confidence interval [CI] 1.84-3.60) and infection (AHR 2.49, 95% CI 1.02-6.07). Effect of antimicrobial drugs on MRSA colonization and infection was similar to effect on CDAD and should be considered when selecting antimicrobial drugs to treat common infections.
• Subjects:
  Adolescent Adult Aged Aged, 80 And Over Anti-Infective Agents Clostridium Difficile Enterocolitis, Pseudomembranous Female Fluoroquinolones Humans Male Methicillin Methicillin Resistance Microbial Sensitivity Tests Middle Aged Risk Factors Staphylococcal Infections Staphylococcus Aureus

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• Source:
  Emerg Infect Dis. 12(9):1398-1405.
• Document Type:
  Journal Article
• Place as Subject:
  Quebec, Canada
• Location:
  North America
• Volume:
  12
• Issue:
  9
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:ae628107736abaa92a273c88f110c02fae02f0792cde1d64ebcba10218035e02
• Download URL:
  https://stacks.cdc.gov/view/cdc/16309/cdc_16309_DS1.pdf
• File Type:
  [PDF - 343.64 KB ]