Genomic Signatures of Human versus Avian Influenza A Viruses

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Chen, Guang-Wu ; Chang, Shih-Cheng ; Mok, Chee-Keng ; Lo, Yu-Luan ; Kung, Yu-Nong ; Huang, Ji-Hung ; Shih, Yun-Han ; Wang, Ji-Yi ; Chiang, Chiayn ; Chen, Chi-Jene ; Shih, Shin-Ru
• Description:
  Position-specific entropy profiles created from scanning 306 human and 95 avian influenza A viral genomes showed that 228 of 4591 amino acid residues yielded significant differences between these 2 viruses. We subsequently used 15,785 protein sequences from the National Center for Biotechnology Information (NCBI) to assess the robustness of these signatures and obtained 52 "species-associated" positions. Specific mutations on those points may enable an avian influenza virus to become a human virus. Many of these signatures are found in NP, PA, and PB2 genes (viral ribonucleoproteins [RNPs]) and are mostly located in the functional domains related to RNP-RNP interactions that are important for viral replication. Upon inspecting 21 human-isolated avian influenza viral genomes from NCBI, we found 19 that exhibited > or =1 species-associated residue changes; 7 of them contained > or =2 substitutions. Histograms based on pairwise sequence comparison showed that NP disjointed most between human and avian influenza viruses, followed by PA and PB2.
• Subjects:
  Amino Acid Sequence Animals Avian Influenza Birds Genome Genome, Viral Host Specificity Human Influenza Humans Influenza, Human Influenza A Virus Influenza A Virus, H5N1 Subtype Influenza A Virus, H7N7 Subtype Influenza A Virus, H9N2 Subtype Influenza In Birds Molecular Sequence Data Mutation Research Sequence Analysis Sequence Analysis, DNA Species Specificity Viral Proteins

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• Source:
  Emerg Infect Dis. 12(9):1353-1360.
• Document Type:
  Journal Article
• Volume:
  12
• Issue:
  9
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:5ca6670f5c5a965f038b148d18ce11c47898cb38b8ba8bc2311382ac35c6328a
• Download URL:
  https://stacks.cdc.gov/view/cdc/16262/cdc_16262_DS1.pdf
• File Type:
  [PDF - 344.80 KB ]