Streptococcus suis Sequence Type 7 Outbreak, Sichuan, China

Ye, Changyun; Zhu, Xiaoping; Jing, Huaiqi; Du, Huamao; Segura, Mariela; Zheng, Han; Kan, Biao; Wang, Lili; Bai, Xuemei; Zhou, Yongyun; Cui, Zhigang; Zhang, Shouying; Jin, Dong; Sun, Na; Luo, Xia; Zhang, Ji; Gong, Zhaolong; Wang, Xin; Wang, Lei; Sun, Hui; Li, Zhenjun; Sun, Qiangzheng; Liu, Honglu; Dong, Boqing; Ke, Changwen; Yuan, Hui; Wang, Hua; Tian, Kecheng; Wang, Yu; Gottschalk, Marcelo; Xu, Jianguo

i

Streptococcus suis Sequence Type 7 Outbreak, Sichuan, China

Supporting Files Public Domain

Aug 2006
By Ye, Changyun ; Zhu, Xiaoping ; Jing, Huaiqi ; ...

File Language:

English

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Alternative Title:

Emerg Infect Dis
Personal Author:

Ye, Changyun ; Zhu, Xiaoping ; Jing, Huaiqi ; Du, Huamao ; Segura, Mariela ; Zheng, Han ; Kan, Biao ; Wang, Lili ; Bai, Xuemei ; Zhou, Yongyun ; Cui, Zhigang ; Zhang, Shouying ; Jin, Dong ; Sun, Na ; Luo, Xia ; Zhang, Ji ; Gong, Zhaolong ; Wang, Xin ; Wang, Lei ; Sun, Hui ; Li, Zhenjun ; Sun, Qiangzheng ; Liu, Honglu ; Dong, Boqing ; Ke, Changwen ; Yuan, Hui ; Wang, Hua ; Tian, Kecheng ; Wang, Yu ; Gottschalk, Marcelo ; Xu, Jianguo
Description:

An outbreak of Streptococcus suis serotype 2 emerged in the summer of 2005 in Sichuan Province, and sporadic infections occurred in 4 additional provinces of China. In total, 99 S. suis strains were isolated and analyzed in this study: 88 isolates from human patients and 11 from diseased pigs. We defined 98 of 99 isolates as pulse type I by using pulsed-field gel electrophoresis analysis of SmaI-digested chromosomal DNA. Furthermore, multilocus sequence typing classified 97 of 98 members of the pulse type I in the same sequence type (ST), ST-7. Isolates of ST-7 were more toxic to peripheral blood mononuclear cells than ST-1 strains. S. suis ST-7, the causative agent, was a single-locus variant of ST-1 with increased virulence. These findings strongly suggest that ST-7 is an emerging, highly virulent S. suis clone that caused the largest S. suis outbreak ever described.
Subjects:

Animals Disease Outbreaks DNA, Bacterial Electrophoresis, Gel, Pulsed-Field Humans Molecular Sequence Data Phylogeny Polymerase Chain Reaction Research Sequence Analysis, DNA Serotyping Streptococcal Infections Swine Swine Diseases Virulence
Source:

Emerg Infect Dis. 12(8):1203-1208.
Document Type:

Journal Article
Place as Subject:

China
Location:

Asia
Volume:

12
Issue:

8
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:6f45a680295aa05a3a4bc5eb10ca4e5213779ea416602287dec55e51b83127c7
Download URL:

https://stacks.cdc.gov/view/cdc/16253/cdc_16253_DS1.pdf
File Type:

[PDF - 192.08 KB ]

File Language:

English

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