An Evaluation of the Performance, Patient Acceptability and Feasibility of a Point-of-Care HIV-Syphilis Assay in an Urban Emergency Department

Details

• Alternative Title:
  Sex Transm Dis
• Personal Author:
  Maliszewski, Kendall N. ; Hsieh, Yu-Hsiang ; Curbeam, Deanna ; Rizkallah, Ann ; Perez, Danielle A. ; Dashler, Gaby ; Ricketts, Erin P. ; Rompalo, Anne M. ; Gaydos, Charlotte A. ; Manabe, Yukari C. ; Melendez, Johan ; Rothman, Richard E.
• Description:
  Background:
  
  Point-of-care (POC) tests for sexually transmitted infections (STIs) permit delivery of results during the patient’s emergency department (ED) encounter. We evaluated performance, patient acceptability, and feasibility of a new duplex POC test, Chembio DPP® HIV-Syphilis Assay in an urban ED setting.
  
  Methods:
  
  Convenience sampling approach prioritizing those considered at increased risk for an STI and/or with a history of HIV. For the performance evaluation, participants were tested for HIV/syphilis with the Chembio POC assay, and the reference laboratory tests; sensitivity and specificity were determined. For the patient acceptability evaluation, participants completed pre- and post-user surveys. For the feasibility evaluation, ED clinical technicians completed a survey evaluating their perceptions regarding feasibility of use of this POC test.
  
  Results:
  
  327 patients were consented and enrolled. The diagnostic sensitivity and specificity of the Chembio POC assay for HIV was 96.5% (95% CI: 90.1%, 99.3%) and 99.6% (95% CI: 97.7%, 100.0%), respectively, and for syphilis was 93.9% (95% CI: 85.0%, 98.3%) and 99.6% (95% CI: 97.9%, 100.0%), respectively. Regarding patient acceptability: 87% trusted the result; and 93% reported they were more likely to seek treatment if they received a positive STI test result in the ED rather than after the ED visit. Regarding feasibility: 90% of the technicians reported they would recommend using the test in EDs.
  
  Conclusions:
  
  The Chembio DPP® HIV-Syphilis POC assay had excellent performance characteristics when evaluated in an ED population, as well as high perceived acceptability from patients, and feasibility for ED use from clinical technicians. The test may have utility for HIV-syphilis screening among high-risk ED patients.
  
  
• Subjects:
  Adult Emergency Service, Hospital Feasibility Studies Female HIV Infections Humans Male Middle Aged Patient Acceptance Of Health Care Point-of-Care Systems Point-of-Care Testing Sensitivity And Specificity Syphilis Urban Population Young Adult

  More +
• Keywords:
  Diagnostics Emergency Department HIV Linkage To Care Point-of-Care Test Sexually Transmitted Infection
• Source:
  Sex Transm Dis. 51(10):648-653
• Pubmed ID:
  38722756
• Pubmed Central ID:
  PMC11392641
• Document Type:
  Journal Article
• Funding:
  U01 PS005204/PS/NCHHSTP CDC HHSUnited States/ ; U54 EB007958/EB/NIBIB NIH HHSUnited States/
• Volume:
  51
• Issue:
  10
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:61f6e30b3c0edf265c4fb3b81863c7f8dc4bfa4371a1ff10b558170b92868defe2e682099423cede29966add256ae2e9d8c2a4ec164995b34cd6d67524e327bf
• Download URL:
  https://stacks.cdc.gov/view/cdc/162406/cdc_162406_DS1.pdf
• File Type:
  [PDF - 926.47 KB ]