An adjusted partial least squares regression framework to utilize additional exposure information in environmental mixture data analysis

Details

• Alternative Title:
  J Appl Stat
• Personal Author:
  Du, Ruofei ; Luo, Li ; Hudson, Laurie G. ; Nozadi, Sara ; Lewis, Johnnye
• Description:
  In a large-scale environmental health population study that is composed of subprojects, often different fractions of participants out of the total enrolled have measures of specific outcomes. It's conceptually reasonable to assume the association study would benefit from utilizing additional exposure information from those with a specific outcome not measured. Partial least squares regression is a practical approach to determine the exposure-outcome associations for mixture data. Like a typical regression approach, however, the partial least squares regression requires that each data observation must have both complete covariate and outcome for model fitting. In this paper, we propose novel adjustments to the general partial least squares regression to estimate and examine the association effects of individual environmental exposure to an outcome within a more complete context of the study population's environmental mixture exposures. The proposed framework takes advantage of the bilinear model structure. It allows information from all participants, with or without the outcome values, to contribute to the model fitting and the assessment of association effects. Using this proposed framework, incorporation of additional information will lead to smaller root mean square errors in the estimation of association effects, and improve the ability to assess the significance of the effects.
• Keywords:
  Adjusted SIMPLS Birth Cohort Metal Mixture Exposure Mixture Analysis Navajo
• Source:
  J Appl Stat. 50(8):1790-1811
• Pubmed ID:
  37260474
• Pubmed Central ID:
  PMC10228318
• Document Type:
  Journal Article
• Funding:
  P50 ES026102/ES/NIEHS NIH HHSUnited States/ ; P42 ES025589/ES/NIEHS NIH HHSUnited States/ ; UH3 OD023344/OD/NIH HHSUnited States/ ; P50 MD015706/MD/NIMHD NIH HHSUnited States/ ; U01 TS000135/TS/ATSDR CDC HHSUnited States/ ; R01 ES021100/ES/NIEHS NIH HHSUnited States/ ; UG3 OD023344/OD/NIH HHSUnited States/
• Volume:
  50
• Issue:
  8
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:6d01945c87f7e1169a309f18ac9b380b7854f8bf40a279c0561628979059cd4ad281a59e2c2dd5bfeef2c24ec45b54dfa63fcb6a029734b67a482e831f7a6d01
• Download URL:
  https://stacks.cdc.gov/view/cdc/162352/cdc_162352_DS1.pdf
• File Type:
  [PDF - 682.95 KB ]