Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Rolain, Jean-Marc ; Lepidi, Hubert ; Zanaret, Michel ; Triglia, Jean-Michel ; Michel, Gérard ; ... More +
Rolain, Jean-Marc ; Lepidi, Hubert ; Zanaret, Michel ; Triglia, Jean-Michel ; Michel, Gérard ; Thomas, Pascal-Alexandre ; Texereau, Michèle ; Stein, Andreas ; Romaru, Anette ; Eb, François ; Raoult, Didier Less -
Description:
We report microbiologic analysis of 786 lymph node biopsy specimens from patients with suspected cat-scratch disease (CSD). The specimens were examined by standard, cell culture, and molecular methods. Infectious agents were found in samples from 391 (49.7%) of 786 patients. The most commonly identified infectious agent was Bartonella henselae (245 patients, 31.2%), the agent of CSD. Mycobacteriosis was diagnosed in 54 patients (6.9%) by culture and retrospectively confirmed by using a specific real-time PCR assay. Neoplasm was diagnosed in 181 specimens suitable for histologic analysis (26.0%) from 47 patients. Moreover, 13 patients with confirmed Bartonella infections had concurrent mycobacteriosis (10 cases) or neoplasm (3 cases). A diagnosis of CSD does not eliminate a diagnosis of mycobacteriosis or neoplasm. Histologic analysis of lymph node biopsy specimens should be routinely performed because some patients might have a concurrent malignant disease or mycobacteriosis.
Subjects:
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16S RRNA Adolescent Adult Aged Aged, 80 And Over Animals Bacteriological Techniques Bartonella Bartonella Henselae Biopsy Cat-scratch Disease Cats Child Child, Preschool Culture Media DNA, Bacterial Female Humans Infant Lymphadenopathy Lymph Nodes Male Middle Aged Mycobacteria Mycobacterium Infections Neoplasms Polymerase Chain Reaction Research RNA, Ribosomal, 16S
Source:
Emerg Infect Dis. 12(9):1338-1344.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
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urn:sha256:d1f6619271be754ad47512e1d46ef810830315efe227a2c80a43a50f85c71fd4
Download URL:
https://stacks.cdc.gov/view/cdc/16227/cdc_16227_DS1.pdf
File Type:

Supporting Files

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