Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Rolain, Jean-Marc ; Lepidi, Hubert ; Zanaret, Michel ; Triglia, Jean-Michel ; Michel, Gérard ; ... More +
Rolain, Jean-Marc ; Lepidi, Hubert ; Zanaret, Michel ; Triglia, Jean-Michel ; Michel, Gérard ; Thomas, Pascal-Alexandre ; Texereau, Michèle ; Stein, Andreas ; Romaru, Anette ; Eb, François ; Raoult, Didier Less -
Description:
We report microbiologic analysis of 786 lymph node biopsy specimens from patients with suspected cat-scratch disease (CSD). The specimens were examined by standard, cell culture, and molecular methods. Infectious agents were found in samples from 391 (49.7%) of 786 patients. The most commonly identified infectious agent was Bartonella henselae (245 patients, 31.2%), the agent of CSD. Mycobacteriosis was diagnosed in 54 patients (6.9%) by culture and retrospectively confirmed by using a specific real-time PCR assay. Neoplasm was diagnosed in 181 specimens suitable for histologic analysis (26.0%) from 47 patients. Moreover, 13 patients with confirmed Bartonella infections had concurrent mycobacteriosis (10 cases) or neoplasm (3 cases). A diagnosis of CSD does not eliminate a diagnosis of mycobacteriosis or neoplasm. Histologic analysis of lymph node biopsy specimens should be routinely performed because some patients might have a concurrent malignant disease or mycobacteriosis.
Subject:
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16S RRNA
Adolescent
Adult
Aged
Aged, 80 And Over
Animals
Bacteriological Techniques
Bartonella
Bartonella Henselae
Biopsy
Cat-Scratch Disease
Cats
Child
Child, Preschool
Culture Media
DNA, Bacterial
Female
Humans
Infant
Lymphadenopathy
Lymph Nodes
Male
Middle Aged
Mycobacteria
Mycobacterium Infections
Neoplasms
Polymerase Chain Reaction
Research
RNA, Ribosomal, 16S
Cat-scratch Disease

Source:
Emerg Infect Dis. 12(9):1338-1344.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
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urn:sha256:d1f6619271be754ad47512e1d46ef810830315efe227a2c80a43a50f85c71fd4
File Type:

Supporting Files

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