Lymph Node Biopsy Specimens and Diagnosis of Cat-scratch Disease

Rolain, Jean-Marc; Lepidi, Hubert; Zanaret, Michel; Triglia, Jean-Michel; Michel, Gérard; Thomas, Pascal-Alexandre; Texereau, Michèle; Stein, Andreas; Romaru, Anette; Eb, François; Raoult, Didier

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Lymph Node Biopsy Specimens and Diagnosis of Cat-scratch Disease

Published Date:

Sep 2006

Source:

Emerg Infect Dis. 12(9):1338-1344.

[PDF-126.34 KB]

Details:

Personal Authors:

Rolain, Jean-Marc ; Lepidi, Hubert ; Zanaret, Michel ; Triglia, Jean-Michel ; Michel, Gérard ; ... More ▼

Keywords:

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Description:

We report microbiologic analysis of 786 lymph node biopsy specimens from patients with suspected cat-scratch disease (CSD). The specimens were examined by standard, cell culture, and molecular methods. Infectious agents were found in samples from 391 (49.7%) of 786 patients. The most commonly identified infectious agent was Bartonella henselae (245 patients, 31.2%), the agent of CSD. Mycobacteriosis was diagnosed in 54 patients (6.9%) by culture and retrospectively confirmed by using a specific real-time PCR assay. Neoplasm was diagnosed in 181 specimens suitable for histologic analysis (26.0%) from 47 patients. Moreover, 13 patients with confirmed Bartonella infections had concurrent mycobacteriosis (10 cases) or neoplasm (3 cases). A diagnosis of CSD does not eliminate a diagnosis of mycobacteriosis or neoplasm. Histologic analysis of lymph node biopsy specimens should be routinely performed because some patients might have a concurrent malignant disease or mycobacteriosis.

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

Supporting Files:

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