Lymph Node Biopsy Specimens and Diagnosis of Cat-scratch Disease

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Rolain, Jean-Marc ; Lepidi, Hubert ; Zanaret, Michel ; Triglia, Jean-Michel ; Michel, Gérard ; Thomas, Pascal-Alexandre ; Texereau, Michèle ; Stein, Andreas ; Romaru, Anette ; Eb, François ; Raoult, Didier
  More +
• Description:
  We report microbiologic analysis of 786 lymph node biopsy specimens from patients with suspected cat-scratch disease (CSD). The specimens were examined by standard, cell culture, and molecular methods. Infectious agents were found in samples from 391 (49.7%) of 786 patients. The most commonly identified infectious agent was Bartonella henselae (245 patients, 31.2%), the agent of CSD. Mycobacteriosis was diagnosed in 54 patients (6.9%) by culture and retrospectively confirmed by using a specific real-time PCR assay. Neoplasm was diagnosed in 181 specimens suitable for histologic analysis (26.0%) from 47 patients. Moreover, 13 patients with confirmed Bartonella infections had concurrent mycobacteriosis (10 cases) or neoplasm (3 cases). A diagnosis of CSD does not eliminate a diagnosis of mycobacteriosis or neoplasm. Histologic analysis of lymph node biopsy specimens should be routinely performed because some patients might have a concurrent malignant disease or mycobacteriosis.
• Subjects:
  • Research
  • Bartonella
  • lymphadenopathy
  • cat-scratch disease
  • 16S rRNA
  • mycobacteria
  • research
  • Adolescent
  • Adult
  • Aged
  More +
• Source:
  Emerg Infect Dis. 12(9):1338-1344.
• Document Type:
  Journal Article
• Volume:
  12
• Issue:
  9
• Download URL:
  https://stacks.cdc.gov/view/cdc/16227/cdc_16227_DS1.pdf
• File Type:
  [PDF - 126.34 KB]
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:d1f6619271be754ad47512e1d46ef810830315efe227a2c80a43a50f85c71fd4