Multidrug-resistant Commensal Escherichia coli in Children, Peru and Bolivia

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Bartoloni, Alessandro ; Pallecchi, Lucia ; Benedetti, Marta ; Fernandez, Connie ; Vallejos, Yolanda ; Guzman, Elisa ; Villagran, Ana Liz ; Mantella, Antonia ; Lucchetti, Chiara ; Bartalesi, Filippo ; Strohmeyer, Marianne ; Bechini, Angela ; Gamboa, Herlan ; Rodríguez, Hugo ; Falkenberg, Torkel ; Kronvall, Göran ; Gotuzzo, Eduardo ; Paradisi, Franco ; Rossolini, Gian Maria
• Description:
  Using a rapid screening method, we investigated the prevalence of fecal carriage of antimicrobial drug-resistant Escherichia coli in 3,174 healthy children from 4 urban settings in Peru and Bolivia. High resistance rates were observed for ampicillin (95%), trimethoprim-sulfamethoxazole (94%), tetracycline (93%), streptomycin (82%), and chloramphenicol (70%). Lower resistance rates were observed for nalidixic acid (35%), kanamycin (28%), gentamicin (21%), and ciprofloxacin (18%); resistance to ceftriaxone and amikacin was uncommon (<0.5%). In a random sample of 1,080 resistant E. coli isolates, 90% exhibited a multidrug-resistance (MDR) phenotype. The 2 most common MDR phenotypes (ampicillin/tetracycline/trimethoprim-sulfamethoxazole and ampicillin/tetracycline/trimethoprim-sulfamethoxazole/chloramphenicol) could be transferred en bloc in conjugation experiments. The most common acquired resistance genes were blaTEM, tet(A), tet(B), drfA8, sul1, sul2, and catI. These findings underscore the magnitude of the problem of antimicrobial drug resistance in low-resource settings and the urgent need for surveillance and control of this phenomenon.
• Subjects:
  Child Child, Preschool Cohort Studies DNA, Bacterial Drug Resistance, Multiple, Bacterial Feces Female Humans Infant Male Microbial Sensitivity Tests Polymerase Chain Reaction Prevalence Urban Population

  More +
• Source:
  Emerg Infect Dis. 12(6):907-913.
• Document Type:
  Journal Article
• Place as Subject:
  Peru ; Bolivia
• Volume:
  12
• Issue:
  6
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:fdfc04e1a2be63f28fc9f78f74da05d9040806b642186cef92cc83596aad5622
• Download URL:
  https://stacks.cdc.gov/view/cdc/16103/cdc_16103_DS1.pdf
• File Type:
  [PDF - 187.67 KB ]