Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Thomas, Paul G. ; Keating, Rachael ; Hulse-Post, Diane J. ; Doherty, Peter C. ;
Thomas, Paul G. ; Keating, Rachael ; Hulse-Post, Diane J. ; Doherty, Peter C. ; Less -
Description:
Current vaccine strategies against influenza focus on generating robust antibody responses. Because of the high degree of antigenic drift among circulating influenza strains over the course of a year, vaccine strains must be reformulated specifically for each influenza season. The time delay from isolating the pandemic strain to large-scale vaccine production would be detrimental in a pandemic situation. A vaccine approach based on cell-mediated immunity that avoids some of these drawbacks is discussed here. Specifically, cell-mediated responses typically focus on peptides from internal influenza proteins, which are far less susceptible to antigenic variation. We review the literature on the role of CD4+ and CD8+ T cell-mediated immunity in influenza infection and the available data on the role of these responses in protection from highly pathogenic influenza infection. We discuss the advantages of developing a vaccine based on cell-mediated immune responses toward highly pathogenic influenza virus and potential problems arising from immune pressure.
Subject:
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Animals
CD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
Cell-mediated Immunity
Highly Pathogenic Virus
Humans
Immunity, Cellular
Influenza
Influenza, Human
Influenza Vaccines
Models, Immunological
Perspective
Vaccine
Perspective

Source:
Emerg Infect Dis. 12(1):48-54.
Document Type:
Journal Article ;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
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urn:sha256:aec0a54204fa26b4988f5ce8de7ea1112f5b3e3535f036df03fce4a31ebb67d2
File Type:

Supporting Files

• 	05-1237-F.gif	gif
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