Cell-mediated Protection in Influenza Infection

Thomas, Paul G.; Keating, Rachael; Hulse-Post, Diane J.; Doherty, Peter C.

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Cell-mediated Protection in Influenza Infection

Published Date:

Jan 2006

Source:

Emerg Infect Dis. 12(1):48-54.

[PDF-103.31 KB]

Details:

Alternative Title:

Emerg Infect Dis

Personal Author:

Thomas, Paul G. ; Keating, Rachael ; Hulse-Post, Diane J. ; Doherty, Peter C. ;

Description:

Current vaccine strategies against influenza focus on generating robust antibody responses. Because of the high degree of antigenic drift among circulating influenza strains over the course of a year, vaccine strains must be reformulated specifically for each influenza season. The time delay from isolating the pandemic strain to large-scale vaccine production would be detrimental in a pandemic situation. A vaccine approach based on cell-mediated immunity that avoids some of these drawbacks is discussed here. Specifically, cell-mediated responses typically focus on peptides from internal influenza proteins, which are far less susceptible to antigenic variation. We review the literature on the role of CD4+ and CD8+ T cell-mediated immunity in influenza infection and the available data on the role of these responses in protection from highly pathogenic influenza infection. We discuss the advantages of developing a vaccine based on cell-mediated immune responses toward highly pathogenic influenza virus and potential problems arising from immune pressure.

Subject:

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Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

Main Document Checksum:

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Cell-mediated Protection in Influenza Infection

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