Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid1304.051195
Personal Author:
Wang, Jann-Yuan; Chou, Chien-Hong; Lee, Li-Na; Hsu, Hsiao-Leng; Jan, I-Shiow; ... More +
Wang, Jann-Yuan; Chou, Chien-Hong; Lee, Li-Na; Hsu, Hsiao-Leng; Jan, I-Shiow; Hsueh, Po-Ren; Yang, Pan-Chyr; Luh, Kwen-Tay; Less -
Description:
We evaluated an enzyme-linked immunospot assay for interferon-gamma (T SPOT-TB) for rapid diagnosis of active tuberculosis (TB) in a disease-endemic area. From January to June 2005, patients whose clinical symptoms and radiographic findings were compatible with TB were recruited, and a blood sample was obtained for T SPOT-TB assay within 7 days of microbiologic studies. Sixty-five patients were studied, including 39 (60%) with active TB. Thirty-five (53.8%) patients had underlying medical conditions. Thirty-seven patients had positive cultures for Mycobacterium tuberculosis, and 11 patients had positive cultures for nontuberculous mycobacteria. The sensitivity, specificity, positive predictive value, and negative predictive value of the T SPOT-TB assay were 87.2%, 88.5%, 91.9%, and 82.1%, respectively. The accuracy of this test in diagnosing active TB is >80%, even in an area with a high incidence of nontuberculous mycobacterial disease.
Subject:
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Adolescent
Adult
Aged
Aged, 80 And Over
Child
Child, Preschool
Culture Media
ELISPOT
Enzyme-Linked Immunosorbent Assay
Female
Humans
Interferon-gamma
Interferon-γ
Latent Infection
Leukocytes, Mononuclear
Lymphocyte Activation
Male
Middle Aged
Mycobacterium Tuberculosis
Predictive Value Of Tests
Research
Sensitivity And Specificity
Tuberculosis

Source:
Emerg Infect Dis. 13(4):553-558.;
Document Type:
Journal Article;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:b55a494b87458aa8d9f220bd7f33d405d698202950843612842a50e7e9c02ab4
File Type:

Supporting Files

• 	05-1195.nxml	txt
  	license.txt	txt

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