Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Wang, Jann-Yuan ; Chou, Chien-Hong ; Lee, Li-Na ; Hsu, Hsiao-Leng ; Jan, I-Shiow ; ... More +
Wang, Jann-Yuan ; Chou, Chien-Hong ; Lee, Li-Na ; Hsu, Hsiao-Leng ; Jan, I-Shiow ; Hsueh, Po-Ren ; Yang, Pan-Chyr ; Luh, Kwen-Tay Less -
Description:
We evaluated an enzyme-linked immunospot assay for interferon-gamma (T SPOT-TB) for rapid diagnosis of active tuberculosis (TB) in a disease-endemic area. From January to June 2005, patients whose clinical symptoms and radiographic findings were compatible with TB were recruited, and a blood sample was obtained for T SPOT-TB assay within 7 days of microbiologic studies. Sixty-five patients were studied, including 39 (60%) with active TB. Thirty-five (53.8%) patients had underlying medical conditions. Thirty-seven patients had positive cultures for Mycobacterium tuberculosis, and 11 patients had positive cultures for nontuberculous mycobacteria. The sensitivity, specificity, positive predictive value, and negative predictive value of the T SPOT-TB assay were 87.2%, 88.5%, 91.9%, and 82.1%, respectively. The accuracy of this test in diagnosing active TB is >80%, even in an area with a high incidence of nontuberculous mycobacterial disease.
Subjects:
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Adolescent Adult Aged Aged, 80 And Over Child Child, Preschool Culture Media ELISPOT Enzyme-Linked Immunosorbent Assay Female Humans Interferon-gamma Interferon-γ Latent Infection Leukocytes, Mononuclear Lymphocyte Activation Male Middle Aged Mycobacterium Tuberculosis Predictive Value Of Tests Research Sensitivity And Specificity Tuberculosis
Source:
Emerg Infect Dis. 13(4):553-558.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
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urn:sha256:b55a494b87458aa8d9f220bd7f33d405d698202950843612842a50e7e9c02ab4
Download URL:
https://stacks.cdc.gov/view/cdc/16092/cdc_16092_DS1.pdf
File Type:

Supporting Files

• 	05-1195.nxml	txt
  	license.txt	txt

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