Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
García-Sastre, Adolfo
Description:
The outcome of viral infections depends on a complex set of interactions between the viruses and their hosts. Particularly, viral infection triggers specific signaling programs within the infected cells that results in substantial changes in host gene expression. While some of these changes might be beneficial for viral replication, others represent the induction of a host antiviral response. In this respect, viruses have evolved genes that counteract this initial innate antiviral response. These viral-host interactions shape the subsequent phases of the disease and influence the adaptive immune response. In influenza viruses, the nonstructural protein 1 inhibits the interferon-mediated antiviral response. The regulatory activities of this viral protein play a major role in the pathogenicity of influenza virus and appear partially responsible for the ability of influenza viruses to infect multiple animal species, which likely contributes to the generation of new pandemic viruses in humans.
Subject:
[+]
Disease Outbreaks
Humans
Influenza
Influenza, Human
Influenza A Virus
Influenza Vaccines
Interferon
Interferons
NS1
Perspective
Viral Nonstructural Proteins

Source:
Emerg Infect Dis. 12(1):44-47.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:c0ad44db567a1938d1e41d8e78aeaf607efc5c3c958297175b7460a768601d8b
File Type:

Supporting Files

• 	05-1186.nxml	txt
  	license.txt	txt

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