Enterobacter cloacae Outbreak and Emergence of Quinolone Resistance Gene in Dutch Hospital

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Paauw, Armand ; Fluit, Ad C. ; Verhoef, Jan ; Leverstein-van Hall, Maurine A.
• Description:
  An outbreak of Enterobacter cloacae infections with variable susceptibility to fluoroquinolones occurred in the University Medical Center Utrecht in the Netherlands in 2002. Our investigation showed that a qnrA1 gene was present in 78 (94%) of 83 outbreak isolates and that a qnrA1-encoding plasmid transferred to other strains of the same species and other species. The earliest isolate carrying this same plasmid was isolated in 1999. qnrA1 was located in a complex integron consisting of the intI1, aadB, qacEDelta1, sul1, orf513, qnrA1, ampR, qacEDelta1, and sul1 genes that were not described previously. On the same plasmid, 2 other class 1 integrons were present. One was a new integron associated with the bla(CTX-M-9) extended-spectrum beta-lactamase.
• Subjects:
  • Dispatch
  • Research
  • qnrA
  • Enterobacter cloacae
  • integron
  • fluoroquinolones
  • plasmid-mediated
  • qnr
  • CTX-M-9
  • aminoglycoside
  More +
• Source:
  Emerg Infect Dis. 12(5):807-812.
• Document Type:
  Journal Article
• Volume:
  12
• Issue:
  5
• Download URL:
  https://stacks.cdc.gov/view/cdc/16023/cdc_16023_DS1.pdf
• File Type:
  [PDF - 186.57 KB]
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:ace168647b28884a656fb19fd673054ae5cd8638c69ff8b2fd00ff249ed27d15