Enterobacter cloacae Outbreak and Emergence of Quinolone Resistance Gene in Dutch Hospital

Paauw, Armand; Fluit, Ad C.; Verhoef, Jan; Leverstein-van Hall, Maurine A.

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Enterobacter cloacae Outbreak and Emergence of Quinolone Resistance Gene in Dutch Hospital

Published Date:

May 2006

Source:

Emerg Infect Dis. 12(5):807-812.

[PDF-186.57 KB]

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Alternative Title:

Emerg Infect Dis

Personal Author:

Paauw, Armand ; Fluit, Ad C. ; Verhoef, Jan ; Leverstein-van Hall, Maurine A. ;

Description:

An outbreak of Enterobacter cloacae infections with variable susceptibility to fluoroquinolones occurred in the University Medical Center Utrecht in the Netherlands in 2002. Our investigation showed that a qnrA1 gene was present in 78 (94%) of 83 outbreak isolates and that a qnrA1-encoding plasmid transferred to other strains of the same species and other species. The earliest isolate carrying this same plasmid was isolated in 1999. qnrA1 was located in a complex integron consisting of the intI1, aadB, qacEDelta1, sul1, orf513, qnrA1, ampR, qacEDelta1, and sul1 genes that were not described previously. On the same plasmid, 2 other class 1 integrons were present. One was a new integron associated with the bla(CTX-M-9) extended-spectrum beta-lactamase.

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Journal Article

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Emerging Infectious Diseases

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Enterobacter cloacae Outbreak and Emergence of Quinolone Resistance Gene in Dutch Hospital

Enterobacter cloacae Outbreak and Emergence of Quinolone Resistance Gene in Dutch Hospital

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