Enterobacter cloacae Outbreak and Emergence of Quinolone Resistance Gene in Dutch Hospital
Published Date:May 2006
Source:Emerg Infect Dis. 12(5):807-812.
Communicable Diseases, Emerging
Drug Resistance, Bacterial
Electrophoresis, Gel, Pulsed-Field
Microbial Sensitivity Tests
Molecular Sequence Data
Description:An outbreak of Enterobacter cloacae infections with variable susceptibility to fluoroquinolones occurred in the University Medical Center Utrecht in the Netherlands in 2002. Our investigation showed that a qnrA1 gene was present in 78 (94%) of 83 outbreak isolates and that a qnrA1-encoding plasmid transferred to other strains of the same species and other species. The earliest isolate carrying this same plasmid was isolated in 1999. qnrA1 was located in a complex integron consisting of the intI1, aadB, qacEDelta1, sul1, orf513, qnrA1, ampR, qacEDelta1, and sul1 genes that were not described previously. On the same plasmid, 2 other class 1 integrons were present. One was a new integron associated with the bla(CTX-M-9) extended-spectrum beta-lactamase.
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