Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Paauw, Armand ; Fluit, Ad C. ; Verhoef, Jan ; Leverstein-van Hall, Maurine A.
Paauw, Armand ; Fluit, Ad C. ; Verhoef, Jan ; Leverstein-van Hall, Maurine A. Less -
Description:
An outbreak of Enterobacter cloacae infections with variable susceptibility to fluoroquinolones occurred in the University Medical Center Utrecht in the Netherlands in 2002. Our investigation showed that a qnrA1 gene was present in 78 (94%) of 83 outbreak isolates and that a qnrA1-encoding plasmid transferred to other strains of the same species and other species. The earliest isolate carrying this same plasmid was isolated in 1999. qnrA1 was located in a complex integron consisting of the intI1, aadB, qacEDelta1, sul1, orf513, qnrA1, ampR, qacEDelta1, and sul1 genes that were not described previously. On the same plasmid, 2 other class 1 integrons were present. One was a new integron associated with the bla(CTX-M-9) extended-spectrum beta-lactamase.
Subject:
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Aminoglycoside Anti-Bacterial Agents Base Sequence Cluster Analysis Communicable Diseases, Emerging Conjugation, Genetic CTX-M-9 Disease Outbreaks Dispatch Drug Resistance, Bacterial Electrophoresis, Gel, Pulsed-Field Enterobacter Cloacae Enterobacteriaceae Infections Fluoroquinolones Gene Amplification Genotype Humans Integron Microbial Sensitivity Tests Molecular Sequence Data Netherlands Outbreak Phylogeny Plasmid-mediated Plasmids Qnr QnrA Quinolones Research Species Specificity
Source:
Emerg Infect Dis. 12(5):807-812.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:ace168647b28884a656fb19fd673054ae5cd8638c69ff8b2fd00ff249ed27d15
Download URL:
https://stacks.cdc.gov/view/cdc/16023/cdc_16023_DS1.pdf
File Type:

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