Rickettsial Infections and Fever, Vientiane, Laos

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Phongmany, Simaly ; Rolain, Jean-Marc ; Phetsouvanh, Rattanaphone ; Blacksell, Stuart D. ; Soukkhaseum, Vimone ; Rasachack, Bouachanh ; Phiasakha, Khamphong ; Soukkhaseum, Surn ; Frichithavong, Khamthavi ; Chu, Vang ; Keolouangkhot, Valy ; Martinez-Aussel, Bertrand ; Chang, Ko ; Darasavath, Chirapha ; Rattanavong, Oudayvone ; Sisouphone, Siho ; Mayxay, Mayfong ; Vidamaly, Sisouphane ; Parola, Philippe ; Thammavong, Chanpheng ; Heuangvongsy, Mayboun ; Syhavong, Bounkong ; Raoult, Didier ; White, Nicholas J. ; Newton, Paul N.
• Description:
  Rickettsial diseases have not been described previously from Laos, but in a prospective study, acute rickettsial infection was identified as the cause of fever in 115 (27%) of 427 adults with negative blood cultures admitted to Mahosot Hospital in Vientiane, Laos. The organisms identified by serologic analysis were Orientia tsutsugamushi (14.8%), Rickettsia typhi (9.6%), and spotted fever group rickettsia (2.6% [8 R. helvetica, 1 R. felis, 1 R. conorii subsp. indica, and 1 Rickettsia "AT1"]). Patients with murine typhus had a lower frequency of peripheral lymphadenopathy than those with scrub typhus (3% vs. 46%, p<0.001). Rickettsioses are an underrecognized cause of undifferentiated febrile illnesses among adults in Laos. This finding has implications for the local empiric treatment of fever.
• Subjects:
  Adolescent Adult Aged Antibodies, Bacterial Female Fever Humans Immunoglobulin G Immunoglobulin M Laos Male Middle Aged Orientia Tsutsugamushi Prospective Studies Research Rickettsia AT1 Rickettsia Conorii Rickettsia Felis Rickettsia Helvetica Rickettsia Typhi Scrub Typhus Typhus Typhus, Endemic Flea-Borne

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• Source:
  Emerg Infect Dis. 12(2):256-262.
• Document Type:
  Journal Article
• Volume:
  12
• Issue:
  2
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:cebdf45776108a2391056e6f4ca100d42bbe716cb3a1966df0a4f0387fcbd9b8
• Download URL:
  https://stacks.cdc.gov/view/cdc/16020/cdc_16020_DS1.pdf
• File Type:
  [PDF - 156.36 KB ]