Details:

• Alternative Title:
  Birth Defects Res
• Personal Author:
  Slawsky, Erik D. ; Weaver, Anne M. ; Luben, Thomas J. ; Rappazzo, Kristen M.

  Slawsky, Erik D. ; Weaver, Anne M. ; Luben, Thomas J. ; Rappazzo, Kristen M. Less -
• Description:
  Background
  
  Brownfields consist of abandoned and disused sites, spanning many former purposes. Brownfields represent a heterogenous yet ubiquitous exposure for many Americans, which may contain hazardous wastes and represent urban blight. Neonates and pregnant individuals are often sensitive to subtle environmental exposures. We evaluate if residential exposure to lead (Pb) brownfields is associated with birth defects.
  
  Methods
  
  Using North Carolina birth records from 2003–2015, we sampled 169,499 births within 10 kilometers (km) of a Pb brownfield with 3,255 cardiovascular, central nervous, or external defects identified. Exposure was classified by binary specification of residing within 3 kilometers (km) of a Pb brownfield. We utilized multivariable logistic regression models adjusted for demographic covariates available from birth records and 2010 Census to estimate odds ratios (OR) and 95% confidence intervals (CI). Effect measure modification was assessed by inclusion of interaction terms and stratification for the potential modifiers of race/ethnicity and diabetes status.
  
  Results
  
  We observed positive associations between cardiovascular birth defects and residential proximity to Pb brownfields, OR (95%CI): 1.15 (1.04, 1.26), with suggestive positive associations for central nervous 1.16 (0.91, 1.47) and external defects 1.19 (0.88, 1.59). We did observe evidence of effect measure modification via likelihood ratio tests (LRT) for race/ethnicity for central nervous and external defect groups (LRT p-values 0.08 and 0.02). We did observe modification by diabetes status for the cardiovascular group (LRT p-value 0.08).
  
  Conclusions
  
  Our results from this analysis indicate that residential proximity to Pb brownfields is associated with cardiovascular birth defects with suggestive associations for central nervous and external defects. In-depth analyses of individual defects and other contaminants or brownfield site functions may reveal additional novel associations.
  
  
• Subjects:
  [+]

  Adult Case-Control Studies Congenital Abnormalities Cross-Sectional Studies Environmental Exposure Female Humans Infant, Newborn Lead Logistic Models Male North Carolina Odds Ratio Pregnancy
• Keywords:
  [+]

  Birth Defects Brownfields Residential Exposures
• Source:
  Birth Defects Res. 116(8):e2367
• Pubmed ID:
  39136602
• Pubmed Central ID:
  PMC11328954
• Document Type:
  Journal Article
• Funding:
  EPA999999/ImEPA/Intramural EPAUnited States/ ; T42 OH008673/OH/NIOSH CDC HHSUnited States/ ; T42OH008673/OH/NIOSH CDC HHSUnited States/

  EPA999999/ImEPA/Intramural EPAUnited States/ ; T42 OH008673/OH/NIOSH CDC HHSUnited States/ ; T42OH008673/OH/NIOSH CDC HHSUnited States/ Less -
• Volume:
  116
• Issue:
  8
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  [+]

  urn:sha-512:100904e54d3b75791450912bc62843358955d46584e41b9c8cf8ee6399790fd1c898faa6c09d8e2b8259ec277e7ad71f6a914a32c72ddd28f4062023d5029598
• File Type:

• Supporting Files:
  No Additional Files