Details:

• Alternative Title:
  Infect Control Hosp Epidemiol
• Personal Author:
  McCarthy, Natalie L. ; Baggs, James ; Wolford, Hannah ; Kazakova, Sophia V. ; Kabbani, Sarah ; ... More +

  McCarthy, Natalie L. ; Baggs, James ; Wolford, Hannah ; Kazakova, Sophia V. ; Kabbani, Sarah ; Attell, Brandon K. ; Neuhauser, Melinda M. ; Walker, Lindsey ; Yi, Sarah H. ; Hatfield, Kelly M. ; Reddy, Sujan ; Hicks, Lauri A. Less -
• Description:
  Objective:
  
  The 2014 United States National Strategy for Combating Antibiotic-Resistant Bacteria aimed to reduce inappropriate inpatient antibiotic use by 20% for monitored conditions, such as community-acquired pneumonia (CAP), by 2020. We evaluated annual trends in length of therapy (LOT) in adults hospitalized with uncomplicated CAP from 2013–2020.
  
  Methods:
  
  We conducted a retrospective cohort study among adults with a primary diagnosis of bacterial or unspecified pneumonia using International Classification of Diseases 9th and 10th revision codes in MarketScan® and Centers for Medicare & Medicaid Services databases. We included patients with length of stay (LOS) of 2–10 days, discharged home with self-care, and not re-hospitalized in the 3 days following discharge. We estimated inpatient LOT based on LOS from the PINC AI Healthcare Database. Total LOT was calculated by summing estimated inpatient LOT and actual post-discharge LOT. We examined trends from 2013–2020 in patients with total LOT >7 days, which was considered an indicator of likely excessive LOT.
  
  Results:
  
  There were 44,976 and 400,928 uncomplicated CAP hospitalizations among patients 18–64 years and ≥65 years, respectively. From 2013 to 2020, the proportion of patients with total LOT >7 days decreased by 25% (68% to 51%) among patients 18–64 years, and by 27% (68% to 50%) among patients ≥65 years.
  
  Conclusions:
  
  While likely excessive LOT for uncomplicated CAP patients decreased since 2013, the proportion of patients treated with LOT >7 days still exceeded 50% in 2020. Antibiotic stewardship programs should continue to pursue interventions to reduce likely excessive LOT for common infections.
  
  
• Subjects:
  [+]

  Adolescent Adult Aged Aged, 80 And Over Anti-Bacterial Agents Antimicrobial Stewardship Community-Acquired Infections Female Hospitalization Humans Length Of Stay Male Middle Aged Pneumonia Pneumonia, Bacterial Retrospective Studies United States Young Adult
• Keywords:
  [+]

  Antibiotic Stewardship Community-acquired Pneumonia Hospitalization Length Of Antibiotic Therapy Pneumonia
• Source:
  Infect Control Hosp Epidemiol. 45(6):726-732
• Pubmed ID:
  38351597
• Pubmed Central ID:
  PMC11323296
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  45
• Issue:
  6
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  [+]

  urn:sha-512:4a696a322126bee4fa13430f1e7d3b041e2c42e55e3435cb4715da474fd776f1bb8fab103a6aa424fddf6cfa2607f31050ce34ccbc15f1ed581c503294a9f1f8
• File Type:

• Supporting Files:
  No Additional Files