Impact of deceased organ donor marijuana use on donor culture positivity and solid organ transplant recipient outcomes

Details

• Alternative Title:
  Am J Transplant
• Personal Author:
  Moore, Krista ; Lautenbach, Ebbing ; Blumberg, Emily A. ; Han, Jennifer ; Lee, Dong Heun ; Clauss, Heather ; Hasz, Richard ; Bilker, Warren B. ; Molnar, Esther ; Alimenti, Darcy ; West, Sharon ; Tolomeo, Pam ; Anesi, Judith A.
  More +
• Description:
  With the increasing prevalence of marijuana use in the US, many deceased organ donors have a history of marijuana use, raising concerns about infectious risks to transplant recipients. We performed a multicenter retrospective cohort study in which exposed donors were those with recent marijuana use (in the prior 12 months) and unexposed donors were those with no recent marijuana use. Primary outcomes included the following: (1) positive donor cultures for bacteria or fungi, (2) recipient infection due to bacteria or fungi within 3 months posttransplant, and (3) recipient graft failure or death within 12 months posttransplant. Multivariable regression was used to evaluate the relationship between donor marijuana use and each outcome. A total of 658 recipients who received organs from 394 donors were included. Recent marijuana use was not associated with donor culture positivity (aOR: 0.84, 95% CI: 0.39-1.81, P = .65), recipient infection (aHR: 1.02, 95% CI: 0.76-1.38, P = .90), or recipient graft failure or death (aHR: 1.65, 95% CI: 0.90-3.02, P = .11). Our data suggest that organs from donors with a history of recent marijuana use do not pose significant infectious risks in the early posttransplant period.
• Subjects:
  • Humans
  • Male
  • Female
  • Retrospective Studies
  • Tissue Donors
  • Middle Aged
  • Adult
  • Organ Transplantation
  • Risk Factors
  • Transplant Recipients
  More +
• Source:
  Am J Transplant. 24(8):1427-1439
• Pubmed ID:
  38403188
• Pubmed Central ID:
  PMC11305974
• Document Type:
  Journal Article
• Funding:
  K01 AI137317/AI/NIAID NIH HHSUnited States/ ; K24 AI080942/AI/NIAID NIH HHSUnited States/ ; U54 CK000163/CK/NCEZID CDC HHSUnited States/
• Volume:
  24
• Issue:
  8
• Download URL:
  https://stacks.cdc.gov/view/cdc/159752/cdc_159752_DS1.pdf
• File Type:
  [PDF - 855.81 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:de93cebcfcd57d87b81e974db20312c3f0f9e921504e7f1c6c332fcb15ab00fd32c51ce99c1f2b63cc76a8e454e8cbceb247f571f25ac5735b31fc51b2ab12bf