Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Krause, Gérard ; Schöneberg, Irene ; Altmann, Doris ; Stark, Klaus ;
Krause, Gérard ; Schöneberg, Irene ; Altmann, Doris ; Stark, Klaus ; Less -
Description:
To determine the effect of chemoprophylaxis on the case-fatality rate of malaria, we analyzed all cases of Plasmodium falciparum malaria in nonimmune persons reported from 1993 to 2004 in Germany. In univariate and multivariate logistic regression analysis, we determined the effect of age, sex, chemoprophylaxis, chemoprophylactic regimen, compliance for chemoprophylactic regimen, exposure prophylaxis, country of infection, and year of reporting on the outcome. Of 3,935 case-patients, 116 (3%) died of malaria. Univariate analysis showed significant associations with death for chemoprophylaxis with chloroquine plus proguanil compared to no chemoprophylaxis. The multivariate model showed that patients who had taken chemoprophylaxis were less likely to die compared to those who had not taken chemoprophylaxis, adjusted for patient age and reporting year. The study demonstrated that chemoprophylaxis significantly reduced fatality rates among nonimmune malaria patients and supports the importance of existing guidelines for malaria prevention.
Subject:
[+]
Antimalarials
CFR
Chemoprophylaxis
Chloroquine
Female
Germany
Humans
Malaria
Malaria, Falciparum
Male
Multivariate Analysis
Odds Ratio
Plasmodium Falciparum
Research
Retrospective Studies
Risk Factors
Time Factors
Travel
Research

Source:
Emerg Infect Dis. 12(3):447-451.
Document Type:
Journal Article ;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:3c789ca005d357f5e76e3c9e371f736088f36b47736460041921f9aa0d30fca0
File Type:

Supporting Files

• 	05-0736-F.gif	gif
  	05-0736-F.jpg	jpeg
  	05-0736.nxml	txt
  	license.txt	txt

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