SARS Vaccine Development

Jiang, Shibo; He, Yuxian; Liu, Shuwen

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SARS Vaccine Development

Supporting Files Public Domain

Jul 2005
By Jiang, Shibo ; He, Yuxian ; Liu, Shuwen

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Jiang, Shibo ; He, Yuxian ; Liu, Shuwen
Description:

Developing effective and safe vaccines is urgently needed to prevent infection by severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV). The inactivated SARS-CoV vaccine may be the first one available for clinical use because it is easy to generate; however, safety is the main concern. The spike (S) protein of SARS-CoV is the major inducer of neutralizing antibodies, and the receptor-binding domain (RBD) in the S1 subunit of S protein contains multiple conformational neutralizing epitopes. This suggests that recombinant proteins containing RBD and vectors encoding the RBD sequence can be used to develop safe and effective SARS vaccines.
Subjects:

Epitopes Humans Membrane Glycoproteins Neutralizing Epitone Receptor-binding Domain SARS SARS-CoV SARS Virus Severe Acute Respiratory Syndrome Spike Glycoprotein, Coronavirus Spike Protein Synopsis Vaccine Vaccines, Inactivated Viral Envelope Proteins Viral Vaccines
Source:

Emerg Infect Dis. 11(7):1016-1020.
Document Type:

Journal Article
Volume:

11
Issue:

7
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:7a028247701c437d3cb38bb71bfb4ab4f3886215664a7e0ee49875191d40ad1a
Download URL:

https://stacks.cdc.gov/view/cdc/15859/cdc_15859_DS1.pdf
File Type:

[PDF - 95.26 KB ]

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