Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Barkai, Galia ; Greenberg, David ; Givon-Lavi, Noga ; Dreifuss, Eli ; Vardy, Daniel ; ... More +
Barkai, Galia ; Greenberg, David ; Givon-Lavi, Noga ; Dreifuss, Eli ; Vardy, Daniel ; Dagan, Ron ; Less -
Description:
We investigated the association between prescribing antimicrobial agents and antimicrobial resistance of Streptococcus pneumoniae among children with acute otitis media in southern Israel. During a 6-year period, all prescriptions of a sample of approximately 20% of Jewish and Bedouin children <5 years of age were recorded and all pneumococcal isolates from middle ear fluid were collected. Although antimicrobial drug use was significantly higher in Bedouin children, the proportion of S. pneumoniae isolates with penicillin MIC = or > 1.0 microg/mL was significantly higher in Jewish children. In both populations, antimicrobial prescriptions were markedly reduced over time, especially for penicillins and erythromycin. In contrast, azithromycin prescriptions increased from 1998 to 2001 with a parallel increase in macrolide and multidrug resistance. Penicillin resistance was associated with macrolide resistance. These findings strongly suggest that azithromycin affects increased antimicrobial resistance, including multidrug resistance, in S. pneumoniae.
Subject:
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Acute Disease
Anti-Bacterial Agents
Antibiotic Resistance
Arabs
Child, Preschool
Drug Resistance, Bacterial
Humans
Israel
Jews
Keywords: Antibiotics
Microbial Sensitivity Tests
Otitis Media With Effusion
Physician's Practice Patterns
Pneumococcal Infections
Research
Streptococcus Pneumoniae

Source:
Emerg Infect Dis. 11(6):829-837. ;
Document Type:
Journal Article ;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
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urn:sha256:37fa7af7e458978d9517e9ca44914ba44fbf05d262b9bfc5d75cc169174ba76f
File Type:

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