Rifampin-resistant Meningococcal Disease
Published Date:Jun 2005
Source:Emerg Infect Dis. 11(6):977-979.
DNA-Directed RNA Polymerases
Drug Resistance, Bacterial
Keywords: Antibiotic Resistance
Microbial Sensitivity Tests
RNA Polymerase Beta Subunit
Funding:U50/CCU511190-09/CC/ODCDC CDC HHS/United States
Description:Rifampin-resistant meningococcal disease occurred in a child who had completed rifampin chemoprophylaxis for exposure to a sibling with meningococcemia. Susceptibility testing of 331 case isolates found only 1 other case of rifampin-resistant disease in Minnesota, USA, during 11 years of statewide surveillance. Point mutations in the RNA polymerase Beta subunit (rpoB) gene were found in isolates from each rifampin-resistant case-patient.
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