Persistence of Resistant Staphylococcus epidermidis after Single Course of Clarithromycin

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Sjölund, Maria ; Tano, Eva ; Blaser, Martin J. ; Andersson, Dan I. ; Engstrand, Lars
• Description:
  We examined how a common therapy that includes clarithromycin affects normally colonizing Staphylococcus epidermidis. Samples from the nostrils of 5 patients receiving therapy were collected before, immediately after, 1 year after, and 4 years after treatment. From each patient and sample, S. epidermidis strains were isolated and analyzed for clarithromycin susceptibility and presence of the erm(C) gene. We show that macrolide-resistant strains of S. epidermidis were selected during therapy and that the same resistant strain may persist for 4 years, in the absence of further antimicrobial treatment.
• Subjects:
  Anti-Bacterial Agents Antimicrobial Resistance Case-Control Studies Clarithromycin Drug Resistance, Bacterial Humans Macrolides Microbial Sensitivity Tests Research Staphylococcal Infections Staphylococcus Epidermidis Time Factors

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• Source:
  Emerg Infect Dis. 11(9):1389-1393.
• Document Type:
  Journal Article
• Volume:
  11
• Issue:
  9
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:87d05879b64e1afa53afe87b7d4a13194163fc0c8ad0784c8d36f2b570e7bfca
• Download URL:
  https://stacks.cdc.gov/view/cdc/15836/cdc_15836_DS1.pdf
• File Type:
  [PDF - 127.22 KB ]