Persistence of Resistant Staphylococcus epidermidis after Single Course of Clarithromycin

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Sjölund, Maria ; Tano, Eva ; Blaser, Martin J. ; Andersson, Dan I. ; Engstrand, Lars
• Description:
  We examined how a common therapy that includes clarithromycin affects normally colonizing Staphylococcus epidermidis. Samples from the nostrils of 5 patients receiving therapy were collected before, immediately after, 1 year after, and 4 years after treatment. From each patient and sample, S. epidermidis strains were isolated and analyzed for clarithromycin susceptibility and presence of the erm(C) gene. We show that macrolide-resistant strains of S. epidermidis were selected during therapy and that the same resistant strain may persist for 4 years, in the absence of further antimicrobial treatment.
• Subjects:
  • Anti-Bacterial Agents
  • Case-Control Studies
  • Clarithromycin
  • Drug Resistance, Bacterial
  • Drug Resistance, Microbial
  • Humans
  • Macrolides
  • Microbial Sensitivity Tests
  • Staphylococcal Infections
  • Staphylococcus epidermidis
  More +
• Source:
  Emerg Infect Dis. 11(9):1389-1393.
• Document Type:
  Text
• Genre:
  Journal Article
• Volume:
  11
• Issue:
  9
• Download URL:
  https://stacks.cdc.gov/view/cdc/15836/cdc_15836_DS1.pdf
• File Type:
  [PDF - 127.22 KB]
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha-512:d046070ee197da73c368a6e900185cebc9efb36c012042e0291fc6eef00804edd71192db478d6835bf2f11e384336f86330d23d13920c2dc0a5ee71a364f34b1