Human Metapneumovirus Genetic Variability, South Africa

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Ludewick, Herbert P. ; Abed, Yacine ; van Niekerk, Nadia ; Boivin, Guy ; Klugman, Keith P. ; Madhi, Shabir A.
• Description:
  The molecular epidemiology and genetic diversity of the human metapneumovirus (hMPV) were characterized for a 3-year period (2000-2002) from viruses that were identified in South Africa. Two major genetic groups (A and B) and 2 subgroups (1 and 2) of hMPV were identified, as well as 2-6 possible genotypes within the subgroups. A shift in the predominant group was documented in successive seasons. Whereas the F gene was relatively conserved between subgroups, a high degree of variation was observed in the extracellular domain of the G gene of the virus. The G protein identities between groups A and B were 45.1%-53.1% at the nucleotide level and 22.4%-27.6% at the amino acid level. These results provide evidence for the diversity of both surface glycoproteins of hMPV in Africa, which may be a prerequisite to understanding protective immunity against hMPV.
• Subjects:
  • Genetic Variation
  • Humans
  • Metapneumovirus
  • Paramyxoviridae Infections
  • Phylogeny
  • Viral Proteins
• Source:
  Emerg Infect Dis. 11(7):1074-1078.
• Document Type:
  Journal Article
• Place as Subject:
  South Africa
• Volume:
  11
• Issue:
  7
• Download URL:
  https://stacks.cdc.gov/view/cdc/15821/cdc_15821_DS1.pdf
• File Type:
  [PDF - 78.63 KB]
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:16ba5375ae9b34341c091f3f1f1a44b832ab9d3a9a676b758eeb349f6ff1ede8