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Detecting Hepatitis B Surface Antigen Mutants
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Feb 2006
Source: Emerg Infect Dis. 12(2):198-203.
[PDF-122.63 KB]
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Alternative Title:Emerg Infect Dis
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Description:Hepatitis B viral mutants can emerge in patients as a result of selection pressure from either immune response or treatment options. Mutations that occur within the immunodominant epitopes of hepatitis B surface antigen (HBsAg) allow mutant virus to propagate in the presence of a neutralizing immune response, while wild-type virus is reduced to undetectable levels. HBsAg mutants present as false-negative results in some immunoassays. An understanding of immunoassay reactivity with HBsAg mutants is key to establishing an appropriate testing algorithm for hepatitis B virus detection programs.
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