Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Coleman, Paul F. ;
Description:
Hepatitis B viral mutants can emerge in patients as a result of selection pressure from either immune response or treatment options. Mutations that occur within the immunodominant epitopes of hepatitis B surface antigen (HBsAg) allow mutant virus to propagate in the presence of a neutralizing immune response, while wild-type virus is reduced to undetectable levels. HBsAg mutants present as false-negative results in some immunoassays. An understanding of immunoassay reactivity with HBsAg mutants is key to establishing an appropriate testing algorithm for hepatitis B virus detection programs.
Subject:
[+]
Child
HBsAg
Hepatitis B
Hepatitis B Surface Antigens
Hepatitis B Virus
Humans
Immunoassay
Models, Molecular
Mutation
Mutations
Perspective
Reagent Kits, Diagnostic

Source:
Emerg Infect Dis. 12(2):198-203.
Document Type:
Journal Article ;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:bd47f1db31e9f36ffd2591a9c0c50810c8caf2f6648fb43ce685089c37ddfe68
File Type:

Supporting Files

• 	05-0038-F.gif	gif
  	05-0038-F.jpg	jpeg
  	05-0038.nxml	txt
  	license.txt	txt

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