Detecting Hepatitis B Surface Antigen Mutants

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Coleman, Paul F.
• Description:
  Hepatitis B viral mutants can emerge in patients as a result of selection pressure from either immune response or treatment options. Mutations that occur within the immunodominant epitopes of hepatitis B surface antigen (HBsAg) allow mutant virus to propagate in the presence of a neutralizing immune response, while wild-type virus is reduced to undetectable levels. HBsAg mutants present as false-negative results in some immunoassays. An understanding of immunoassay reactivity with HBsAg mutants is key to establishing an appropriate testing algorithm for hepatitis B virus detection programs.
• Subjects:
  Child HBsAg Hepatitis B Hepatitis B Surface Antigens Hepatitis B Virus Humans Immunoassay Models, Molecular Mutation Mutations Perspective Reagent Kits, Diagnostic

  More +
• Source:
  Emerg Infect Dis. 12(2):198-203.
• Document Type:
  Journal Article
• Volume:
  12
• Issue:
  2
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:bd47f1db31e9f36ffd2591a9c0c50810c8caf2f6648fb43ce685089c37ddfe68
• Download URL:
  https://stacks.cdc.gov/view/cdc/15818/cdc_15818_DS1.pdf
• File Type:
  [PDF - 122.63 KB ]