Predominance of Ancestral Lineages of Mycobacterium tuberculosis in India

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Gutierrez, M. Cristina ; Ahmed, Niyaz ; Willery, Eve ; Narayanan, Sujatha ; Hasnain, Seyed E. ; Chauhan, Devendra S. ; Katoch, Vishwa M. ; Vincent, Véronique ; Locht, Camille ; Supply, Philip
• Description:
  Although India has the highest prevalence of tuberculosis (TB) worldwide, the genetic diversity of Mycobacterium tuberculosis in India is largely unknown. A collection of 91 isolates originating from 12 different regions spread across the country were analyzed by genotyping using 21 loci with variable-number tandem repeats (VNTRs), by spoligotyping, by principal genetic grouping (PGG), and by deletion analysis of M. tuberculosis-specific deletion region 1. The isolates showed highly diverse VNTR genotypes. Nevertheless, highly congruent groupings identified by using the 4 independent sets of markers permitted a clear definition of 3 prevalent PGG1 lineages, which corresponded to the "ancestral" East African-Indian, the Delhi, and the Beijing/W genogroups. A few isolates from PGG2 lineages and a single representative of the presumably most recent PGG3 were identified. These observations suggest a predominance of ancestral M. tuberculosis genotypes in the Indian subcontinent, which supports the hypothesis that India is an ancient endemic focus of TB.
• Subjects:
  Adult DNA, Bacterial Evolution, Molecular Female Genetic Variation Genotype Humans Male Middle Aged Minisatellite Repeats Oligonucleotides Polymorphism, Single Nucleotide Research Tuberculosis

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• Source:
  Emerg Infect Dis. 12(9):1367-1374.
• Document Type:
  Journal Article
• Place as Subject:
  India
• Location:
  Asia
• Volume:
  12
• Issue:
  9
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:a14229ada24d9e327299b1d202d08ae0a116b74818995fbca286bdb07a2ba7e7
• Download URL:
  https://stacks.cdc.gov/view/cdc/15815/cdc_15815_DS1.pdf
• File Type:
  [PDF - 211.11 KB ]