Infectious Diseases and Clinical Xenotransplantation

Fishman, Jay A.; Mueller, Nicolas J.

doi:10.3201/eid3007.240273

i

Infectious Diseases and Clinical Xenotransplantation

Supporting Files Public Domain

7 2024
By Fishman, Jay A. ; Mueller, Nicolas J.

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Fishman, Jay A. ; Mueller, Nicolas J.
Description:

Xenotransplantation, transplantation into humans of vascularized organs or viable cells from nonhuman species, is a potential solution to shortages of transplantable human organs. Among challenges to application of clinical xenotransplantation are unknown risks of transmission of animal microbes to immunosuppressed recipients or the community. Experience in allotransplantation and in preclinical models suggests that viral infections are the greatest concern. Worldwide, the distribution of swine pathogens is heterogeneous and cannot be fully controlled by international agricultural regulations. It is possible to screen source animals for potential human pathogens before procuring organs in a manner not possible within the time available for surveillance testing in allotransplantation. Infection control measures require microbiological assays for surveillance of source animals and xenograft recipients and research into zoonotic potential of porcine organisms. Available data suggest that infectious risks of xenotransplantation are manageable and that clinical trials can advance with appropriate protocols for microbiological monitoring of source animals and recipients.
Subjects:

Animals CME Communicable Diseases Humans Infectious Diseases And Clinical Xenotransplantation Perspective Swine Transplantation, Heterologous Zoonoses
Keywords:

Antimicrobial Resistance Assay Development Bacteria Emerging Infection Germ Theory Global Warming Immunocompromised Host Immunosuppression Infection Control Infectious Disease Infectious Diseases Public Health Public Health History Science Pioneers Switzerland United States Viral Infection Xenotransplantation Zoonoses
Source:

Emerg Infect Dis. 2024; 30(7):1311-1318
Pubmed ID:

38916550
Pubmed Central ID:

PMC11210669
Document Type:

Journal Article
Volume:

30
Issue:

7
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha-512:52ec0ccbc225d8acf8f016947f853dbfb426a329b92d6b1669c3ba8c919c86895771c57db7dd2f5419aa4986b56be65048f4e9e3ad1479f520a1c043f0539aa9
Download URL:

https://stacks.cdc.gov/view/cdc/158111/cdc_158111_DS1.pdf
File Type:

[PDF - 681.82 KB ]

File Language:

English

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