Body size throughout adult life influences postmenopausal breast cancer risk among Hispanic women: The Breast Cancer Health Disparities Study

Details

• Alternative Title:
  Cancer Epidemiol Biomarkers Prev
• Personal Author:
  John, Esther M. ; Sangaramoorthy, Meera ; Hines, Lisa M. ; Stern, Mariana C. ; Baumgartner, Kathy B. ; Giuliano, Anna R. ; Wolff, Roger K. ; Slattery, Martha L.
• Description:
  Background
  
  Few studies have assessed the association of body size with postmenopausal breast cancer (BC) risk in Hispanic women. Findings are inconsistent and appear to contradict those reported for non-Hispanic White (NHW) women.
  
  Methods
  
  We pooled interview and anthropometric data for 2,023 Hispanic and 2,384 NHW women from two U.S. population-based case-control studies. Using logistic regression analysis, we examined associations of overall and abdominal adiposity with risk of postmenopausal BC defined by estrogen receptor (ER) and progesterone receptor (PR) status.
  
  Results
  
  Weight gain was associated with increased risk of ER+PR+ BC in Hispanics not currently using menopausal hormone therapy (HT), but only among those with a low young-adult body mass index (BMI). In the subset of Hispanics with data on genetic ancestry, the association with weight gain was limited to women with lower Indigenous American ancestry. Young-adult BMI was inversely associated with both ER+PR+ and ER-PR- BC for both ethnicities combined, with similar, although non-significant, inverse trends in Hispanics and NHWs. Among all Hispanics, regardless of HT use, height was associated with risk of ER-PR-BC and hip circumference with risk of BC overall.
  
  Conclusions
  
  Body size throughout adult life is associated with BC risk among postmenopausal Hispanic women, as has been reported for NHW women. Associations were specific for BC subtypes defined by hormone receptor status.
  
  Impact
  
  Avoiding weight gain and maintaining a healthy weight are important strategies to reduce the risk of postmenopausal ER+PR+ BC, the most common BC subtype.
  
  
• Subjects:
  Adult Body Size Breast Neoplasms Female Healthcare Disparities Hispanic Or Latino Humans Postmenopause Risk Factors Young Adult
• Keywords:
  BMI Body Size Breast Cancer Epidemiology Estrogen Receptor Status Genetic Ancestry Hispanics Latinas Postmenopausal Progesterone Receptor Status Weight Gain

  More +
• Source:
  Cancer Epidemiol Biomarkers Prev. 24(1):128-137
• Pubmed ID:
  25352523
• Pubmed Central ID:
  PMC4295775
• Document Type:
  Journal Article
• Funding:
  CA77305/CA/NCI NIH HHSUnited States/ ; CA078682/CA/NCI NIH HHSUnited States/ ; R01 CA078552/CA/NCI NIH HHSUnited States/ ; R01 CA078762/CA/NCI NIH HHSUnited States/ ; R25 CA174664/CA/NCI NIH HHSUnited States/ ; R01 CA063446/CA/NCI NIH HHSUnited States/ ; CA078552/CA/NCI NIH HHSUnited States/ ; N01-PC-67000/PC/NCI NIH HHSUnited States/ ; CA14002/CA/NCI NIH HHSUnited States/ ; CA078802/CA/NCI NIH HHSUnited States/ ; U58 DP000807/DP/NCCDPHP CDC HHSUnited States/ ; R01 CA078802/CA/NCI NIH HHSUnited States/ ; R01 CA078682/CA/NCI NIH HHSUnited States/
• Volume:
  24
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:ad0be58fa0f7fba7fe92b1c23b92d7508bdff8ab6dbc3b35b89eb834cead7edf
• Download URL:
  https://stacks.cdc.gov/view/cdc/158000/cdc_158000_DS1.pdf
• File Type:
  [PDF - 497.14 KB ]