Maternal physical activity, sitting, and risk of non-cardiac birth defects

Details

• Alternative Title:
  Pediatr Res
• Personal Author:
  Evenson, Kelly R. ; Mowla, Sanjida ; Olshan, Andrew F. ; Shaw, Gary M. ; Ailes, Elizabeth C. ; Reefhuis, Jennita ; Joshi, Neha ; Desrosiers, Tania A.
• Corporate Authors:
  National Birth Defects Prevention Study and Birth Defects Study To Evaluate Pregnancy exposureS
• Description:
  Background:
  
  The relationship between maternal physical activity (PA)/sitting and birth defects is largely unexplored. We examined whether pre-pregnancy PA/sitting were associated with having a pregnancy affected by a birth defect.
  
  Methods:
  
  We used data from two United States population-based case-control studies: 2008–2011 deliveries from the National Birth Defects Prevention Study (NBDPS; 9 states) and 2014–2018 deliveries from the Birth Defects Study To Evaluate Pregnancy exposureS (BD-STEPS; 7 states). Cases with one of 12 non-cardiac birth defects (n=3798) were identified through population-based registries. Controls (n=2682) were live-born infants without major birth defects randomly sampled using vital/hospital records. Mothers self-reported pre-pregnancy PA/sitting. Unconditional logistic regression models estimated associations between PA/sitting categories and the 12 birth defects.
  
  Results:
  
  Mothers engaging in pre-pregnancy PA was associated with a reduced odds of five (spina bifida, cleft palate, anorectal atresia, hypospadias, transverse limb deficiency) and a higher odds of two (anencephaly, gastroschisis) birth defects. Mothers spending less time sitting in pre-pregnancy was associated with a reduced odds of two (anorectal atresia, hypospadias) and a higher odds of one (cleft lip with or without cleft palate) birth defect.
  
  Conclusion:
  
  Reasonable next steps include replication of these findings, improved exposure assessment, and elucidation of biologic mechanisms.
  
  
• Subjects:
  Anorectal Malformations Case-Control Studies Cleft Palate Exercise Female Humans Hypospadias Male Pregnancy Risk Factors United States

  More +
• Source:
  Pediatr Res. 95(1):334-341
• Pubmed ID:
  37543708
• Pubmed Central ID:
  PMC10875984
• Document Type:
  Journal Article
• Funding:
  T32 HD052468/HD/NICHD NIH HHSUnited States/ ; CDP 13-003/HX/HSRD VAUnited States/ ; U01 DD001231/DD/NCBDD CDC HHSUnited States/ ; U01DD001231/ACL/ACL HHSUnited States/ ; EP-D-18-001/EPA/EPAUnited States/
• Volume:
  95
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:44d5948ac605ae71443d22f3628c61b7f2f57351e38301a9e8c511a1a946dfffc8cd03515d78a5aa06dd91456e68b2702b5f7af1080f45a932747305de76e8e8
• Download URL:
  https://stacks.cdc.gov/view/cdc/157929/cdc_157929_DS1.pdf
• File Type:
  [PDF - 458.92 KB ]