Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Carrara, Anne-Sophie ; Gonzales, Marta ; Ferro, Cristina ; Tamayo, Margarita ; Aronson, Judith ; ... More +
Carrara, Anne-Sophie ; Gonzales, Marta ; Ferro, Cristina ; Tamayo, Margarita ; Aronson, Judith ; Paessler, Slobodan ; Anishchenko, Michael ; Boshell, Jorge ; Weaver, Scott C. Less -
Description:
Enzootic strains of Venezuelan equine encephalitis virus (VEEV) circulate in forested habitats of Mexico, Central, and South America, and spiny rats (Proechimys spp.) are believed to be the principal reservoir hosts in several foci. To better understand the host-pathogen interactions and resistance to disease characteristic of many reservoir hosts, we performed experimental infections of F1 progeny from Proechimys chrysaeolus collected at a Colombian enzootic VEEV focus using sympatric and allopatric virus strains. All animals became viremic with a mean peak titer of 3.3 log10 PFU/mL, and all seroconverted with antibody titers from 1:20 to 1:640, which persisted up to 15 months. No signs of disease were observed, including after intracerebral injections. The lack of detectable disease and limited histopathologic lesions in these animals contrast dramatically with the severe disease and histopathologic findings observed in other laboratory rodents and humans, and support their role as reservoir hosts with a long-term coevolutionary relationship to VEEV.
Subjects:
[+]
Alphavirus Animals Antibodies, Viral Biological Evolution Colombia Disease Reservoirs Encephalitis Encephalitis Virus, Venezuelan Equine Lymph Nodes Pathogenesis Research Rodentia Viremia Virus Replication
Source:
Emerg Infect Dis. 11(5):663-669.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:7795305a1b252f8a9d1095566993d24441d320f4f0e15efcd0eed5c0b56839b4
Download URL:
https://stacks.cdc.gov/view/cdc/15782/cdc_15782_DS1.pdf
File Type:

Supporting Files

• 	license.txt	txt
  	04-1251-F1.gif	gif
  	04-1251-F1.jpg	jpeg
  	04-1251-F2.gif	gif
  	04-1251-F2.jpg	jpeg
  	04-1251-F3.gif	gif
  	04-1251-F3.jpg	jpeg
  	04-1251.nxml	txt

More +