Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Stelling, John M. ; Travers, Karin ; Jones, Ronald N. ; Turner, Philip J. ; O'Brien, Thomas F. ; ... More +
Stelling, John M. ; Travers, Karin ; Jones, Ronald N. ; Turner, Philip J. ; O'Brien, Thomas F. ; Levy, Stuart B. Less -
Description:
Collaboration between networks presents opportunities to increase analytical power and cross-validate findings. Multivariate analyses of 2 large, international datasets (MYSTIC and SENTRY) from the Global Advisory on Antibiotic Resistance Data program explored temporal, geographic, and demographic trends in Escherichia coli resistance from 1997 to 2001. Elevated rates of nonsusceptibility were seen in Latin America, southern Europe, and the western Pacific, and lower rates were seen in North America. For most antimicrobial drugs considered, nonsusceptibility was higher in isolates from men, older patients, and intensive care unit patients. Nonsusceptibility to ciprofloxacin was higher in younger patients, rose with time, and was not associated with intensive care unit status. In univariate analyses, estimates of nonsusceptibility from MYSTIC were consistently higher than those from SENTRY, but these differences disappeared in multivariate analyses, which supports the epidemiologic relevance of findings from the 2 programs, despite differences in surveillance strategies.
Subject:
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Anti-Bacterial Agents
Antimicrobial Susceptibility
Data Interpretation, Statistical
Drug Resistance, Bacterial
Drug Resistance Surveillance
Escherichia Coli
Escherichia Coli Infections
Humans
International Cooperation
Keywords: Antimicrobial Resistance
Microbial Sensitivity Tests
Multivariate Analysis
Population Surveillance
Research

Source:
Emerg Infect Dis. 11(6):873-882.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
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urn:sha256:823e48c0abc6720da6b18ff3a39618144e1f6fbed7ecd7948207ff84bb4f2433
File Type:

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