Characteristics of TPT initiation and completion among people living with HIV

Details

• Alternative Title:
  IJTLD Open
• Personal Author:
  Gunde, L. ; Wang, A. ; Payne, D. ; O’Connor, S. ; Kabaghe, A. ; Kalata, N. ; Maida, A. ; Kayira, D. ; Buie, V. ; Tauzi, L. ; Sankhani, A. ; Thawani, A. ; Rambiki, E. ; Ahimbisibwe, A. ; Maphosa, T. ; Kudiabor, K. ; Nyirenda, R. ; Mpunga, J. ; Mbendera, K. ; Nyasulu, P. ; Kayigamba, F. ; Farahani, M. ; Voetsch, A. C. ; Brown, K. ; Jahn, A. ; Girma, B. ; Mirkovic, K.
• Corporate Authors:
  MPHIA Survey Team
• Description:
  BACKGROUND:
  
  TB preventive treatment (TPT) reduces morbidity and mortality among people living with HIV (PLHIV). Despite the successful scale-up of TPT in Malawi, monitoring and evaluation have been suboptimal. We utilized the Malawi Population-Based HIV Impact Assessment (MPHIA) 2020–2021 survey data to estimate TPT uptake and completion among self-reported HIV-positive persons.
  
  METHODS:
  
  We estimated the proportion of HIV-positive respondents who had ever undergone TPT, and determined the percentage of those currently on TPT who had completed more than 6 months of treatment. Bivariate and multivariable logistic regression were performed to calculate the odds ratios for factors associated with ever-taking TPT. All variables were self-reported, and the analysis was weighted and accounted for in the survey design.
  
  RESULTS:
  
  Of the HIV+ respondents, 38.8% (95% CI 36.4–41.3) had ever taken TPT. The adjusted odds of ever taking TPT were 8.0 and 5.2 times as high in the Central and Southern regions, respectively, compared to the Northern region; 1.9 times higher among those in the highest wealth quintile, and 2.1 times higher for those on antiretroviral therapy >10 years. Of those currently taking TPT, 56.2% completed >6 months of TPT.
  
  CONCLUSION:
  
  These results suggest low TPT uptake and >6 months’ completion rates among self-reported HIV+ persons. Initiatives to create demand and strengthen adherence would improve TPT uptake.
  
  
• Keywords:
  Epidemiology Prevention Tuberculosis
• Source:
  IJTLD Open. 1(1):11-19
• Pubmed ID:
  38799089
• Pubmed Central ID:
  PMC11119003
• Document Type:
  Journal Article
• Funding:
  NU2GGH002173/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  1
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:b3293952e732e660bc4799cf0e7c50c9963db9380147800f8ce71bdd66b07b45
• Download URL:
  https://stacks.cdc.gov/view/cdc/157023/cdc_157023_DS1.pdf
• File Type:
  [PDF - 589.55 KB ]