Yersinia ruckeri Infection and Enteric Redmouth Disease among Endangered Chinese Sturgeons, China, 2022

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Yang, Yibin ; Xu, Shijian ; He, Hao ; Zhu, Xia ; Liu, Yongtao ; Hu, Mou ; Jiang, Bobin ; Li, Yuqiang ; Ai, Xiaohui ; Fu, Guihong ; Zhang, Hongyu
• Description:
  During October 2022, enteric redmouth disease (ERM) affected Chinese sturgeons at a farm in Hubei, China, causing mass mortality. Affected fish exhibited characteristic red mouth and intestinal inflammation. Investigation led to isolation of a prominent bacterial strain, zhx1, from the internal organs and intestines of affected fish. Artificial infection experiments confirmed the role of zhx1 as the pathogen responsible for the deaths. The primary pathologic manifestations consisted of degeneration, necrosis, and inflammatory reactions, resulting in multiple organ dysfunction and death. Whole-genome sequencing of the bacteria identified zhx1 as Yersinia ruckeri, which possesses 135 drug-resistance genes and 443 virulence factor-related genes. Drug-susceptibility testing of zhx1 demonstrated high sensitivity to chloramphenicol and florfenicol but varying degrees of resistance to 18 other antimicrobial drugs. Identifying the pathogenic bacteria associated with ERM in Chinese sturgeons establishes a theoretical foundation for the effective prevention and control of this disease.
• Subjects:
  Animals Anti-Bacterial Agents Drug Resistance, Bacterial Fish Diseases Fishes Microbial Sensitivity Tests Whole Genome Sequencing Yersinia Infections Yersinia Ruckeri
• Keywords:
  Acipenser Sinensis Antimicrobial Resistance Bacteria China Chinese Sturgeon Disease Prevention And Control Endangered Enteric Redmouth Disease Species Protection
• Source:
  Emerg Infect Dis. 2024; 30(6):1125-1132
• Pubmed ID:
  38781928
• Pubmed Central ID:
  PMC11138986
• Document Type:
  Journal Article
• Place as Subject:
  China
• Volume:
  30
• Issue:
  6
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:ef5689e3d67c1f9855b24b4144ab8fb1e05a9b859fc134bb31afa965f83968b6
• Download URL:
  https://stacks.cdc.gov/view/cdc/156977/cdc_156977_DS1.pdf
• File Type:
  [PDF - 2.78 MB ]