Age-Related Differences in Past or Present Hepatitis C Virus Infection Among People Who Inject Drugs: National Human Immunodeficiency Virus Behavioral Surveillance, 8 US Cities, 2015

Details

• Alternative Title:
  J Infect Dis
• Personal Author:
  Abara, Winston E. ; Trujillo, Lindsay ; Broz, Dita ; Finlayson, Teresa ; Teshale, Eyasu ; Paz-Bailey, Gabriela ; Glick, Sara ; Al-Tayyib, Alia A. ; Robinson, William T. ; Masiello-Schuette, Stephanie ; Sey, Ekow K. ; Anderson, Bridget J. ; Poe, Jonathon ; Braunstein, Sarah
  More +
• Description:
  Background. ; Historically, older people who inject drugs (PWID) have had the highest hepatitis C virus (HCV) burden; however, young PWID now account for recent increases. We assessed factors associated with past or present HCV infection (HCV antibody anti-HCV positive) among young (≤35 years) and older (>35 years) PWID. ; Methods. ; We calculated adjusted prevalence ratios (aPRs) and 95% confidence intervals (CIs) to examine sociodemographic and past 12-month injection behaviors associated with HCV infection. ; Results. ; Of 4094 PWID, 55.2% were anti-HCV positive. Among young PWID, anti-HCV prevalence was 42.1% and associated with ≤high school diploma/General Education Development diploma (GED) (aPR, 1.17 95% CI, 1.03–1.33), receptive syringe sharing (aPR, 1.37 95% CI, 1.21–1.56), sharing injection equipment (aPR, 1.16 95% CI, 1.01–1.35), arrest history (aPR, 1.14 95% CI, 1.02–1.29), and injecting speedball (aPR, 1.37 95% CI, 1.16–1.61). Among older PWID, anti-HCV prevalence was 62.2% and associated with ≤high school diploma/GED (aPR, 1.08 95% CI, 1.02–1.15), sharing injection equipment (aPR, 1.08 95% CI, 1.02–1.15), high injection frequency (aPR, 1.16 95% CI, 1.01–1.34), and injecting speedball (aPR, 1.09 95% CI, 1.01–1.16) ; Conclusions. ; Anti-HCV prevalence is high among PWID and varies with age. Scaling up direct-acting antiviral treatment, syringe service programs, and medication-assisted therapy is critical to mitigating transmission risk and infection burden.
• Subjects:
  • Adult
  • Antiviral Agents
  • Cities
  • Female
  • HIV
  • HIV Infections
  • Hepacivirus
  • Hepatitis C
  • Humans
  • Male
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• Keywords:
  • direct-acting antiviral treatment
  • HCV
  • hepatitis C
  • heroin
  • medication-assisted treatment
  • opioid use
  • people who inject drugs
  • young people who inject drugs
• Source:
  J Infect Dis. 220(3):377-385
• Pubmed ID:
  30915477
• Pubmed Central ID:
  PMC11111175
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  220
• Issue:
  3
• Download URL:
  https://stacks.cdc.gov/view/cdc/156933/cdc_156933_DS1.pdf
• File Type:
  [PDF - 395.54 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:03fd3f868792973f6a4efd0f214ed4050e0a96ce630172a65903f9a68c7f0c07