Rodent-associated Bartonella Febrile Illness, Southwestern United States

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Iralu, Jonathan ; Bai, Ying ; Crook, Larry ; Tempest, Bruce ; Simpson, Gary ; McKenzie, Taylor ; Koster, Frederick
• Description:
  Serum specimens from 114 patients hospitalized with a febrile illness were tested with an indirect immunofluorescence assay (IFA) using Bartonella antigens prepared from 6 species of sigmodontine rodents and 3 known human Bartonella pathogens: B. henselae, B. quintana, and B. elizabethae. Acute- and convalescent-phase serum samples from 5 of these patients showed seroconversion with an IFA titer >512 to rodent-associated Bartonella antigens. The highest titer was against antigen derived from the white-throated woodrat (Neotoma albigula), although this rodent is not necessarily implicated as the source of infection. Three of the 5 who seroconverted showed no cross-reaction to the 3 Bartonella human pathogens. Common clinical characteristics were fever, chills, myalgias, leukopenia, thrombocytopenia, and transaminasemia. Although antibodies to Bartonella are cross-reactive, high-titer seroconversions to rodent-associated Bartonella antigens in adults with common clinical characteristics should stimulate the search for additional Bartonella human pathogens.
• Subjects:
  Adolescent Adult Aged Animals Bartonella Infections Humans Middle Aged Research Rodentia
• Source:
  Emerg Infect Dis. 12(7):1081-1086.
• Document Type:
  Journal Article
• Place as Subject:
  Southwestern United States
• Location:
  North America
• Volume:
  12
• Issue:
  7
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:7fbab350033ce4be82f482b2f4b217c9950749ea94e8dd8f21995c5c8164e278
• Download URL:
  https://stacks.cdc.gov/view/cdc/15615/cdc_15615_DS1.pdf
• File Type:
  [PDF - 237.07 KB ]