Genetic Background of Escherichia coli and Extended-spectrum β-Lactamase Type

Branger, Catherine; Zamfir, Oana; Geoffroy, Sabine; Laurans, Geneviève; Arlet, Guillaume; Thien, Hoang Vu; Gouriou, Stéphanie; Picard, Bertrand; Denamur, Erick

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Genetic Background of Escherichia coli and Extended-spectrum β-Lactamase Type

Supporting Files Public Domain

Jan 2005
By Branger, Catherine ; Zamfir, Oana ; Geoffroy, Sabine ; ...

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Alternative Title:

Emerg Infect Dis
Personal Author:

Branger, Catherine ; Zamfir, Oana ; Geoffroy, Sabine ; Laurans, Geneviève ; Arlet, Guillaume ; Thien, Hoang Vu ; Gouriou, Stéphanie ; Picard, Bertrand ; Denamur, Erick
Description:

To assess the implication of the genetic background of Escherichia coli strains in the emergence of extended-spectrum-Beta -lactamases (ESBL), 55 TEM-, 52 CTX-M-, and 22 SHV-type ESBL-producing clinical isolates involved in various extraintestinal infections or colonization were studied in terms of phylogenetic group, virulence factor (VF) content (pap, sfa/foc, hly, and aer genes), and fluoroquinolone resistance. A factorial analysis of correspondence showed that SHV type, and to a lesser extent TEM type, were preferentially observed in B2 phylogenetic group strains that exhibited numerous VFs but were fluoroquinolone-susceptible, whereas the newly emerged CTX-M type was associated with the D phylogenetic group strains that lacked VF but were fluoroquinolone-resistant. Thus, the emergence of ESBL-producing E. coli seems to be the result of complex interactions between the type of ESBL, genetic background of the strain, and selective pressures in ecologic niches.
Subjects:

Anti-Bacterial Agents Beta-Lactamases Ciprofloxacin Communicable Diseases, Emerging Drug Resistance, Bacterial Escherichia Coli Escherichia Coli Infections Escherichia Coli Proteins Extended-spectrum β-lactamase Fluoroquinolone Resistance Fluoroquinolones Humans Microbial Sensitivity Tests Phylogenetic Group Phylogeny Polymerase Chain Reaction Research Virulence Virulence Factors
Source:

Emerg Infect Dis. 11(1):54-61.
Document Type:

Journal Article
Volume:

11
Issue:

1
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:a32b2bf0b1ad902a972e0bcf2d57d884f309797af09db3f8eb0441664fc63c34
Download URL:

https://stacks.cdc.gov/view/cdc/15606/cdc_15606_DS1.pdf
File Type:

[PDF - 179.56 KB ]

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