Analysis of Suspected Measles Cases with Discrepant Measles-Specific IgM and rRT-PCR Test Results, Japan

Kuba, Yumani; Nidaira, Minoru; Maeshiro, Noriyuki; Komase, Katsuhiro; Kamiya, Hajime; Kyan, Hisako

doi:10.3201/eid3005.231757

i

Analysis of Suspected Measles Cases with Discrepant Measles-Specific IgM and rRT-PCR Test Results, Japan

Supporting Files Public Domain

5 2024
By Kuba, Yumani ; Nidaira, Minoru ; Maeshiro, Noriyuki ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Kuba, Yumani ; Nidaira, Minoru ; Maeshiro, Noriyuki ; Komase, Katsuhiro ; Kamiya, Hajime ; Kyan, Hisako
Description:

We investigated clinically suspected measles cases that had discrepant real-time reverse transcription PCR (rRT-PCR) and measles-specific IgM test results to determine diagnoses. We performed rRT-PCR and measles-specific IgM testing on samples from 541 suspected measles cases. Of the 24 IgM-positive and rRT-PCR--negative cases, 20 were among children who received a measles-containing vaccine within the previous 6 months; most had low IgG relative avidity indexes (RAIs). The other 4 cases were among adults who had an unknown previous measles history, unknown vaccination status, and high RAIs. We detected viral nucleic acid for viruses other than measles in 15 (62.5%) of the 24 cases with discrepant rRT-PCR and IgM test results. Measles vaccination, measles history, and contact history should be considered in suspected measles cases with discrepant rRT-PCR and IgM test results. If in doubt, measles IgG avidity and PCR testing for other febrile exanthematous viruses can help confirm or refute the diagnosis.
Subjects:

Adolescent Adult Antibodies, Viral Child Child, Preschool Female Humans Immunoglobulin G Immunoglobulin M Infant Male Measles Measles Vaccine Measles Virus Real-Time Polymerase Chain Reaction Young Adult
Keywords:

Febrile Exanthematous Viruses IgG Avidity IgM Testing Japan Vaccine-preventable Diseases Viruses
Source:

Emerg Infect Dis. 2024; 30(5):926-933
Pubmed ID:

38579738
Pubmed Central ID:

PMC11060445
Document Type:

Journal Article
Place as Subject:

Japan
Volume:

30
Issue:

5
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:6f393f7bb018fb6abe11f92f672e82a41d0df775d985694ae9bfe4dfd013b94f
Download URL:

https://stacks.cdc.gov/view/cdc/154883/cdc_154883_DS1.pdf
File Type:

[PDF - 515.79 KB ]

File Language:

English

ON THIS PAGE

Details Supporting Files

CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.

As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.