Crimean Congo Hemorrhagic Fever Virus for Clinicians—Virology, Pathogenesis, and Pathology

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Frank, Maria G. ; Weaver, Gretchen ; Raabe, Vanessa
• Corporate Authors:
  State of the Clinical Science Working Group of the National Emerging Pathogens Training and Education Center’s Special Pathogens Research Network
• Description:
  Crimean-Congo hemorrhagic fever (CCHF), caused by CCHF virus, is a tickborne disease that can cause a range of illness outcomes, from asymptomatic infection to fatal viral hemorrhagic fever; the disease has been described in >30 countries. We conducted a literature review to provide an overview of the virology, pathogenesis, and pathology of CCHF for clinicians. The virus life cycle and molecular interactions are complex and not fully described. Although pathogenesis and immunobiology are not yet fully understood, it is clear that multiple processes contribute to viral entry, replication, and pathological damage. Limited autopsy reports describe multiorgan involvement with extravasation and hemorrhages. Advanced understanding of CCHF virus pathogenesis and immunology will improve patient care and accelerate the development of medical countermeasures for CCHF.
• Subjects:
  Animals Hemorrhagic Fever, Crimean Hemorrhagic Fever Virus, Crimean-Congo Humans Ticks Virus Replication
• Keywords:
  Bunyavirus Countermeasure Crimean-Congo Hemorrhagic Fever Treatment Vaccine Vector-borne Infections Viral Hemorrhagic Fever Viruses
• Source:
  Emerg Infect Dis. 2024; 30(5):847-853
• Pubmed ID:
  38666566
• Pubmed Central ID:
  PMC11060449
• Document Type:
  Journal Article
• Genre:
  Synopsis
• Volume:
  30
• Issue:
  5
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:fd43f66c1b2bac59f887e68dd0c9f726f21150ad06dbfb3c248594b7b9a7945f
• Download URL:
  https://stacks.cdc.gov/view/cdc/154876/cdc_154876_DS1.pdf
• File Type:
  [PDF - 1.43 MB ]