Details:

• Alternative Title:
  Pediatr Res
• Personal Author:
  Alger, Jackeline ; Cafferata, María Luisa ; López, Raquel ; Wiggins, Lisa D. ; Callejas, Allison ; ... More +

  Alger, Jackeline ; Cafferata, María Luisa ; López, Raquel ; Wiggins, Lisa D. ; Callejas, Allison ; Castillo, Mario ; Fúnes, Jenny ; Rico, Fátima ; Valencia, Diana ; Varela, Douglas ; Alvarez, Zulma ; Berrueta, Mabel ; Bock, Harry ; Bustillo, Carolina ; Calderón, Alejandra ; Ciganda, Alvaro ; García-Aguilar, Jorge ; García, Kimberly ; Gibbons, Luz ; Gilboa, Suzanne M. ; Harville, Emily W. ; Hernández, Gustavo ; López, Wendy ; Lorenzana, Ivette ; Luque, Marco T. ; Maldonado, Carlos ; Moore, Cynthia ; Ochoa, Carlos ; Parham, Leda ; Pastrana, Karla ; Paternina-Caicedo, Angel ; Rodríguez, Heriberto ; Stella, Candela ; Tannis, Ayzsa F. ; Wesson, Dawn M. ; Zúniga, Concepción ; Tong, Van T. ; Buekens, Pierre Less -
• Description:
  BACKGROUND:
  
  Studies examining the association between in utero Zika virus (ZIKV) exposure and child neurodevelopmental outcomes have produced varied results.
  
  METHODS:
  
  We aimed to assess neurodevelopmental outcomes among normocephalic children born from pregnant people enrolled in the Zika in Pregnancy in Honduras (ZIPH) cohort study, July–December 2016. Enrollment occurred during the first prenatal visit. Exposure was defined as prenatal ZIKV IgM and/or ZIKV RNA result at enrollment. Normocephalic children, >6 months old, were selected for longitudinal follow-up using the Bayley Scales of Infant and Toddler Development (BSID-III) and the Ages & Stages Questionnaires: Social-Emotional (ASQ:SE-2).
  
  RESULTS:
  
  One hundred fifty-two children were assessed;after exclusion, 60 were exposed and 72 were unexposed to ZIKV during pregnancy. Twenty children in the exposed group and 21 children in the unexposed group had a composite score <85 in any of the BSID-III domains. Although exposed children had lower cognitive and language scores, differences were not statistically significant. For ASQ:SE-2 assessment, there were not statistically significant differences between groups.
  
  CONCLUSIONS:
  
  This study found no statistically significant differences in the neurodevelopment of normocephalic children between in utero ZIKV exposed and unexposed. Nevertheless, long-term monitoring of children with in utero ZIKV exposure is warranted.
  
  
• Subjects:
  [+]

  Child Development Cohort Studies Craniosynostoses Female Humans Infant Infant, Newborn Pregnancy Pregnancy Complications, Infectious Prenatal Exposure Delayed Effects Zika Virus Zika Virus Infection
• Source:
  Pediatr Res. 95(2):566-572
• Pubmed ID:
  38057577
• Pubmed Central ID:
  PMC11045253
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  95
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  [+]

  urn:sha-512:d78d1df6730e444409a21a533531aeb6ab0c3caabeec0fc159b87e4b3bdbc3c9615fd511331cd3d00a75449d18b692ce1d06c29c6f3090a7a0f357995a7e32df
• File Type:

• Supporting Files:
  No Additional Files