Six- and 12-month functional outcomes among patients with confirmed acute flaccid myelitis (AFM) with onset in 2018, United States

Details

• Alternative Title:
  J Pediatr Rehabil Med
• Personal Author:
  Lopez, Adriana S ; Kidd, Sarah ; Yee, Eileen ; Dooling, Kathleen ; Routh, Janell A
• Description:
  Purpose:
  
  Acute flaccid myelitis (AFM), an uncommon but serious neurologic condition, primarily affects children, and can progress quickly to paralysis and respiratory failure. Data on long-term outcomes of patients with AFM are limited. We report on functional status through 12 months for AFM patients who became ill in 2018 in the United States.
  
  Methods:
  
  Health departments collected information on outcomes at 6 and 12 months after onset of AFM using a standardized form that asked patients or their parents/guardians about functional status. Analyses were restricted to confirmed cases.
  
  Results:
  
  Of the 238 confirmed AFM cases reported to CDC in 2018, 90 (38%) had assessments at 6 months, 82 (34%) at 12 months, and 49 (21%) at both 6 and 12 months. Among the 49 patients with data at both time points, the proportion of patients reporting significant or severe impairment at 6 months ranged from 2% to 59% depending on the outcome. Although proportions decreased by 12 months and ranged from 2% to 51%, most patients had some impairment at 12 months. No deaths were reported.
  
  Conclusions:
  
  Six- and 12-month outcomes in patients with onset of AFM in 2018 span a wide range of functionality, particularly of upper and lower extremities. Importantly, improvement appears to occur over time in some patients.
  
  
• Subjects:
  Central Nervous System Viral Diseases Child Humans Lower Extremity Myelitis Neuromuscular Diseases
• Keywords:
  Acute Flaccid Myelitis Functional Outcomes Impairment
• Source:
  J Pediatr Rehabil Med. 16(2):391-400
• Pubmed ID:
  37182848
• Pubmed Central ID:
  PMC11019776
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Place as Subject:
  United States
• Volume:
  16
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:91b7e41826b60194b3ab6db7873e0c97dfaff609d3406cc77979c4db6e62b156
• Download URL:
  https://stacks.cdc.gov/view/cdc/154402/cdc_154402_DS1.pdf
• File Type:
  [PDF - 1.11 MB ]