Multimodal Surveillance Model for Enterovirus D68 Respiratory Disease and Acute Flaccid Myelitis among Children in Colorado, USA, 2022

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Messacar, Kevin ; Matzinger, Shannon ; Berg, Kevin ; Weisbeck, Kirsten ; Butler, Molly ; Pysnack, Nicholas ; Nguyen-Tran, Hai ; Davizon, Emily Spence ; Bankers, Laura ; Jung, Sarah A. ; Birkholz, Meghan ; Wheeler, Allison ; Dominguez, Samuel R.
• Description:
  Surveillance for emerging pathogens is critical for developing early warning systems to guide preparedness efforts for future outbreaks of associated disease. To better define the epidemiology and burden of associated respiratory disease and acute flaccid myelitis (AFM), as well as to provide actionable data for public health interventions, we developed a multimodal surveillance program in Colorado, USA, for enterovirus D68 (EV-D68). Timely local, state, and national public health outreach was possible because prospective syndromic surveillance for AFM and asthma-like respiratory illness, prospective clinical laboratory surveillance for EV-D68 among children hospitalized with respiratory illness, and retrospective wastewater surveillance led to early detection of the 2022 outbreak of EV-D68 among Colorado children. The lessons learned from developing the individual layers of this multimodal surveillance program and how they complemented and informed the other layers of surveillance for EV-D68 and AFM could be applied to other emerging pathogens and their associated diseases.
• Subjects:
  Central Nervous System Viral Diseases Child Enterovirus D, Human Humans Myelitis Neuromuscular Diseases Prospective Studies Respiratory Tract Diseases Retrospective Studies Wastewater Wastewater-Based Epidemiological Monitoring

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• Keywords:
  Acute Flaccid Myelitis Colorado Disease Outbreak Enterovirus D68 EV-D68 Surveillance United States Viruses
• Source:
  Emerg Infect Dis. 2024; 30(3):423-431
• Pubmed ID:
  38407198
• Pubmed Central ID:
  PMC10902548
• Document Type:
  Journal Article
• Place as Subject:
  Colorado
• Volume:
  30
• Issue:
  3
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:22d8b487760f05bfad105fd2079f367a11ffb727d7d4203cb9745d7168f5d7c6
• Download URL:
  https://stacks.cdc.gov/view/cdc/148792/cdc_148792_DS1.pdf
• File Type:
  [PDF - 1.73 MB ]