CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.
As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.
i
Bias Correction in Estimating Proportions by Imperfect Pooled Testing
-
2021
-
Source: J Agric Biol Environ Stat. 26:90-104
[PDF-569.25 KB]
Details:
-
Alternative Title:J Agric Biol Environ Stat
-
Personal Author:
-
Description:In the estimation of proportions by pooled testing, the MLE is biased. Hepworth and Biggerstaff (JABES, 22:602-614, 2017) proposed an estimator based on the bias correction method of Firth (Biometrika 80:27-38, 1993) and showed that it is almost unbiased across a range of pooled testing problems involving no misclassification. We now extend their work to allow for imperfect testing. We derive the estimator, provide a Newton-Raphson iterative formula for its computation and test it in situations involving equal or unequal pool sizes, drawing on problems encountered in plant disease assessment and prevalence estimation of mosquito-borne viruses. Our estimator is highly effective at reducing the bias for prevalences consistent with the pooled testing procedure employed.
-
Keywords:
-
Source:
-
Pubmed ID:38618153
-
Pubmed Central ID:PMC11010583
-
Document Type:
-
Funding:
-
Volume:26
-
Collection(s):
-
Main Document Checksum:
-
Download URL:
-
File Type:
