Prolonged mpox disease in people with advanced HIV: characterization of mpox skin lesions

O’Shea, Jesse; Zucker, Jason; Stampfer, Samuel; Cash-Goldwasser, Shama; Minhaj, Faisal S.; Dretler, Alexandra; Cheeley, Justin; Chaudhuri, Shaoli; Gallitano, Stephanie M.; Gunaratne, Shauna; Parkinson, Melissa; Epling, Brian; Morcock, David R.; Sereti, Irini; Deleage, Claire

doi:10.1093/infdis/jiad532

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Prolonged mpox disease in people with advanced HIV: characterization of mpox skin lesions

11 29 2023
By O’Shea, Jesse ; Zucker, Jason ; Stampfer, Samuel ; ...
Source: J Infect Dis. 229(Suppl 2):S243-S248

Public Access Version Available on: March 26, 2025, 12:00 AM

Please check back on the date listed above.

English

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Alternative Title:

J Infect Dis
Personal Author:

O’Shea, Jesse ; Zucker, Jason ; Stampfer, Samuel ; Cash-Goldwasser, Shama ; Minhaj, Faisal S. ; ... More +

O’Shea, Jesse ; Zucker, Jason ; Stampfer, Samuel ; Cash-Goldwasser, Shama ; Minhaj, Faisal S. ; Dretler, Alexandra ; Cheeley, Justin ; Chaudhuri, Shaoli ; Gallitano, Stephanie M. ; Gunaratne, Shauna ; Parkinson, Melissa ; Epling, Brian ; Morcock, David R. ; Sereti, Irini ; Deleage, Claire Less -
Description:

We report 3 complicated and prolonged cases of mpox in people with advanced human immunodeficiency virus (HIV) not on antiretroviral therapy (ART) at mpox diagnosis. Multiple medical countermeasures were used, including prolonged tecovirimat treatment and immune optimization with ART initiation. Immunofluorescence of skin biopsies demonstrated a dense immune infiltrate of predominantly myeloid and CD8+ T cells, with a strong type I interferon local response. RNAscope detected abundant replication of monkeypox virus (MPXV) in epithelial cells and dendritic cells. These data suggest that prolonged mpox in people with advanced HIV may be due to ongoing MPXV replication, warranting aggressive medical countermeasures and immune optimization.
Subjects:

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Benzamides HIV HIV Infections Humans Mpox (monkeypox) Skin Diseases
Keywords:

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AIDS Monkeypox Virus Mpox Orthopoxvirus
Source:

J Infect Dis. 229(Suppl 2):S243-S248
Pubmed ID:

38019806
Pubmed Central ID:

PMC10965209
Document Type:

Journal Article
Funding:

CC999999/ImCDC/Intramural CDC HHSUnited States/ ; HHSN261201500003C/CA/NCI NIH HHSUnited States/ ; HHSN261201500003I/CA/NCI NIH HHSUnited States/ ; 775N91019D00024/NH/NIH HHSUnited States/

CC999999/ImCDC/Intramural CDC HHSUnited States/ ; HHSN261201500003C/CA/NCI NIH HHSUnited States/ ; HHSN261201500003I/CA/NCI NIH HHSUnited States/ ; 775N91019D00024/NH/NIH HHSUnited States/ Less -
Volume:

229
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha-512:966f75e1d4a634c1a1ca9fb8e7ce42b2b9538fdccac47b9a04ab3402f49c49c0260587a94bd951ff1717ffb289624df75dc4dfff9a6c7284b04ad24aa9856f21
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