CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.
As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.
i
Recent and occult hepatitis B virus infections among blood donors in the United States
-
2 2019
-
-
Source: Transfusion. 59(2):601-611
[PDF-1.38 MB]
Details:
-
Alternative Title:Transfusion
-
Personal Author:
-
Description:BACKGROUND:
Characteristics of US blood donors with recent (RBI) or occult (OBI) hepatitis B virus (HBV) infection are not well defined.
METHODS:
Donors with RBI and OBI were identified by nucleic acid and serologic testing among 34.4 million donations during 2009–2015. Consenting donors were interviewed and their HBV S-gene sequenced.
RESULTS:
The overall rate of HBV-infected donors was 7.95 per 100,000; of these, 0.35 per 100,000 and 1.70 per 100,000 were RBI and OBI, respectively. RBI (n = 120) and OBI (n = 583) donors constituted 26% of all HBV-infected (n = 2735) donors. Detection of HBV DNA in 92% of OBI donors required individual donation nucleic acid testing. Donors with OBI compared to RBI were older (mean age, 48 vs 39 years; p < 0.0001) with lower median viral loads (9 vs. 529 IU/mL; p < 0.0001). A higher proportion of OBI than RBI donors were born or resided in an endemic country (39% vs. 5%; p= 0.0078). Seventy-seven percent of all RBI and OBI donors had multiple sex partners, an HBV-riskfactor. Of 40 RBI and 10 OBI donors whose S gene was sequenced, 33 (83%) and 6 (60%), respectively, carried HBV subgenotype A2; 18 (55%) and 2 (33%), respectively, shared an identical sequence. Infection with 1 or more putative HBV-immune-escape mutants was identified in 5 (50%) of OBI but no RBI donors.
CONCLUSION:
RBI and OBI continue to be identified at low rates, confirming the importance of comprehensive HBV DNA screening of US blood donations. HBV-infected donors require referral for care and evaluation and contact tracing; their HBV strains may provide important information on emergent genotypes.
-
Subjects:
-
Source:
-
Pubmed ID:30499591
-
Pubmed Central ID:PMC8190636
-
Document Type:
-
Funding:
-
Place as Subject:
-
Volume:59
-
Issue:2
-
Collection(s):
-
Main Document Checksum:
-
Download URL:
-
File Type:
