Incidence of Adolescent Syncope and Related Injuries Following Vaccination and Routine Venipuncture

Details

• Alternative Title:
  J Adolesc Health
• Personal Author:
  Groom, Holly C. ; Brooks, Neon B. ; Weintraub, Eric S. ; Slaughter, Matthew T. ; Mittendorf, Kathleen F. ; Naleway, Allison L.
• Description:
  Purpose:
  
  Vaccination is associated with syncope in adolescents. However, incidence of vaccine-associated syncope and resulting injury, and how it compares to syncope incidence following other medical procedures, is not known. Here, we describe the incidence of syncope and syncope-related injury in adolescents following vaccination and routine venipuncture.
  
  Methods:
  
  We identified all Kaiser Permanente Northwest members ages 9–18 years with a vaccination or routine venipuncture and a same-day International Classification of Diseases diagnosis of syncope from 2013 through 2019. All cases were chart reviewed to establish chronology of events (vaccination, venipuncture, syncope, and injury, as applicable) and to attribute cause to vaccination or venipuncture. Incidence rates for vaccine-associated and venipuncture-associated syncope were calculated overall, by sex and age group. Syncope events resulting in injury were assessed for each event type.
  
  Results:
  
  Of 197,642 vaccination and 12,246 venipuncture events identified, 549 vaccination and 67 venipuncture events had same-day syncope codes. Chart validation confirmed 59/549 (10.7%) events as vaccine-associated syncope, for a rate of 2.99 per 10,000 vaccination events (95% confidence interval (CI): 2.27–3.85) and 20/67 (29.9%) events as venipuncture-associated syncope, for a rate of 16.33 per 10,000 venipuncture events (95% CI: 9.98–25.21). The incidence rate ratio of vaccine-associated to venipuncture-associated syncope events was 0.18 (95% CI: 0.11–0.31). The incidence of vaccine-associated syncope increased with each additional simultaneously administered vaccine, from 1.51 per 10,000 vaccination events (95% CI: 0.93–2.30) following a single vaccine to 9.94 per 10,000 vaccination events (95% CI: 6.43–14.67) following three or more vaccines. Syncope resulted in injury in about 15% of both vaccine and venipuncture events.
  
  Discussion:
  
  Syncope occurs more commonly following venipuncture than vaccination. The number of simultaneously administered vaccines is a risk factor for postvaccination syncope in adolescents.
  
  
• Subjects:
  Female Humans Nausea Pregnancy Pregnancy Trimester, First Prescription Drugs Prescriptions United States Vomiting
• Keywords:
  Adolescent Preventive Medicine Vaccination Vasovagal Syncope
• Source:
  J Adolesc Health. 74(4):696-702
• Pubmed ID:
  38069938
• Pubmed Central ID:
  PMC10960660
• Document Type:
  Journal Article
• Funding:
  CDP 13-003/HX/HSRD VAUnited States/ ; U01 DD001304/DD/NCBDD CDC HHSUnited States/ ; U01 DD001224/DD/NCBDD CDC HHSUnited States/ ; U01 DD001227/DD/NCBDD CDC HHSUnited States/ ; CC999999/ImCDC/Intramural CDC HHSUnited States/ ; U01 DD001032/DD/NCBDD CDC HHSUnited States/ ; U01 DD001037/DD/NCBDD CDC HHSUnited States/ ; EP-D-18-001/EPA/EPAUnited States/ ; U01 DD001300/DD/NCBDD CDC HHSUnited States/
• Volume:
  74
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:361af67ad9a02a062c27fecb0f9b9c416c42fce7346f63b1832ceae9649a8761f02f7959c74d8890a2d2adbc105a6c4dd4b6d4a11e489afa8970bb5962287d79
• Download URL:
  https://stacks.cdc.gov/view/cdc/153499/cdc_153499_DS1.pdf
• File Type:
  [PDF - 573.67 KB ]