A mathematical model and CD4+ lymphocyte dynamics in HIV infection.

Hraba, T.; Dolezal, J.

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A mathematical model and CD4+ lymphocyte dynamics in HIV infection.

1996 Oct-Dec
By Hraba, T. ; Dolezal, J.
Source: Emerg Infect Dis. 2(4):299-305.

[PDF-147.23 KB]

English

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Hraba, T. ; Dolezal, J.

Hraba, T. ; Dolezal, J. Less -
Description:

The paper presents a model of CD4 + lymphocyte dynamics in HIV-infected persons. The model incorporates a feedback mechanism regulating the production of T lymphocytes and simulates the dynamics of CD8 + lymphocytes, whose production is assumed to be closely linked to that of CD4 + cells. Because CD4 + lymphocyte counts are a good prognostic indicator of HIV infection, the model was used to simulate such therapeutic interventions as chemotherapy and active and passive immunization. The model also simulated the therapeutic administration of anti-CD8 antibodies; this intervention was assumed to activate T-cell production by activating a feedback mechanism blocked by the high numbers of CD8 + lymphocytes present in HIV-infected persons. The character and implications of the model are discussed in the context of other mathematical models used in HIV infection.
Subjects:

[+]

Antigens, Cd8 Cd4 Lymphocyte Count Cd4-Positive T-Lymphocytes Cd8-Positive T-Lymphocytes Cell Communication Feedback Hiv Infections Humans Immunity, Active Immunization, Passive Immunotherapy Lymphocyte Activation Models, Theoretical Zidovudine
Source:

Emerg Infect Dis. 2(4):299-305.
Document Type:

Journal Article
Volume:

2
Issue:

4
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:4948b2a07c0eee7105b0bb70dc5d4610058d8c2c2f4ac1e17375529be66bd655
Download URL:

https://stacks.cdc.gov/view/cdc/15344/cdc_15344_DS1.pdf
File Type:

	8969246.nxml	txt
	license.txt	txt

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